Relationships between plasma membrane microdomains and HIV-1 assembly.
Relationships between plasma membrane microdomains and HIV-1 assembly.
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DOI：
10.1042/bc20090165
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发表时间：
2010-03-25
影响因子：
2.7
通讯作者：
Ono A
中科院分区：
文献类型：
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作者：
Ono A
细胞生物学和生物物理学的进展表明，细胞膜由多个微域组成，这些微域具有特定的组分，如脂筏和富含四环素的微域。越来越多的包膜病毒被证明在组装过程中利用了这些微域。其中，HIV-1和其他逆转录病毒与质膜内的脂筏和富含四环素的微区之间的联系已被很好地记录下来。在这篇综述中，我将介绍我们目前对质膜微区组织和HIV-1颗粒组装过程之间相互关系的了解。病毒颗粒组装过程中的微域关联也可能调节随后的病毒传播。将讨论微域在两个组装后事件中所起的潜在作用，即RAFT相关蛋白BST-2/tetherin对病毒释放的抑制和病毒学突触的细胞间HIV-1传播。
Advances in cell biology and biophysics revealed that cellular membranes consist of multiple microdomains with specific sets of components such as lipid rafts and tetraspanin-enriched microdomains. An increasing number of enveloped viruses have been shown to utilize these microdomains during their assembly. Among them, association of HIV-1 and other retroviruses with lipid rafts and tetraspanin-enriched microdomains within the plasma membrane is well documented. In this review, I will describe our current knowledge on interrelationships between plasma membrane microdomain organization and the HIV-1 particle assembly process. Microdomain association during virus particle assembly may also modulate subsequent virus spread. Potential roles played by microdomains will be discussed with regard to two post-assembly events, i.e., inhibition of virus release by a raft-associated protein BST-2/tetherin and cell-to-cell HIV-1 transmission at virological synapses.