Genomic perspectives on the evolution of fungal entomopathogenicity in Beauveria bassiana.
Genomic perspectives on the evolution of fungal entomopathogenicity in Beauveria bassiana.
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白僵菌真菌昆虫致病性进化的基因组视角
DOI：
10.1038/srep00483
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发表时间：
2012
影响因子：
4.6
通讯作者：
Feng MG
中科院分区：
文献类型：
--
作者：
Xiao G;Ying SH;Zheng P;Wang ZL;Zhang S;Xie XQ;Shang Y;St Leger RJ;Zhao GP;Wang C;Feng MG
comcycete真菌Bassiana是数百种昆虫物种的病原体，是一种商业生产的，作为一种环保的神经毒剂。我们对B. bassiana的基因组进行了测序，并进行了系统基因分析证实，伴随昆虫病态性是多形的，但也揭示了与昆虫致病性的融合进化。我们还发现许多物种特异性的毒力基因以及基因家族的扩张和收缩与宿主范围和致病策略相关。其中包括B. bassiana具有更多细菌样毒素（表明对口服毒性的潜力无引起的潜力）和效应型蛋白质。该基因组还表明，巴西亚纳（B. bassiana）与密切相关的虫虫军事上有异性，尽管很少观察到其性阶段。高吞吐量RNA-SEQ转录组分析表明，B. bassiana可以通过激活定义明确的基因集来感知并适应不同的环境壁ni。这项研究的信息将促进B. bassiana作为一种具有成本效益的神经毒剂的进一步发展。
The ascomycete fungus Beauveria bassiana is a pathogen of hundreds of insect species and is commercially produced as an environmentally friendly mycoinsecticide. We sequenced the genome of B. bassiana and a phylogenomic analysis confirmed that ascomycete entomopathogenicity is polyphyletic, but also revealed convergent evolution to insect pathogenicity. We also found many species-specific virulence genes and gene family expansions and contractions that correlate with host ranges and pathogenic strategies. These include B. bassiana having many more bacterial-like toxins (suggesting an unsuspected potential for oral toxicity) and effector-type proteins. The genome also revealed that B. bassiana resembles the closely related Cordyceps militaris in being heterothallic, although its sexual stage is rarely observed. A high throughput RNA-seq transcriptomic analysis revealed that B. bassiana could sense and adapt to different environmental niches by activating well-defined gene sets. The information from this study will facilitate further development of B. bassiana as a cost-effective mycoinsecticide.