Haemodynamic analysis of the effect of different types of plaques in the left coronary artery
Haemodynamic analysis of the effect of different types of plaques in the left coronary artery
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DOI：
10.1016/j.compmedimag.2013.02.001
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发表时间：
2013-04-01
影响因子：
5.7
通讯作者：
Jewkes, James
中科院分区：
文献类型：
--
作者：
Chaichana, Thanapong;Sun, Zhonghua;Jewkes, James
目的：冠状动脉斑块已被证明可以直接影响血液参数，但是尚未研究基于斑块结构的血流动力学变化。在本研究中，我们研究了左冠状动脉分叉处各种类型斑块的血流动力学效应。方法：模拟了八种类型的斑块构型，并将其定位在左主干、左前降支和左回旋支的不同位置，以产生> 50％的冠状动脉腔狭窄。我们分析并描述了每种类型斑块引起的血流动力学效应。进行计算流体动力学来模拟真实的生理条件，揭示体内心脏血流动力学。计算并比较心动周期期间所有斑块构型中左冠状动脉的速度、壁剪切应力（WSS）和压力梯度（PSG）。结果：我们的结果表明，在涉及所有三个左冠状动脉分支的斑块构型类型中发现最高的速度和PSG。位于左侧回旋支的斑块导致速度、WSS 和 PSG 发生高度显着的变化 (p
Purpose: Coronary plaque has been shown to directly affect the blood parameters, however, haemodynamic variations based on the plaque configuration has not been studied. In this study we investigate the haemodynamic effects of various types of plaques in the left coronary bifurcation.Methods: Eight types of plaque configurations were simulated and located in various positions in the left main stem, the left anterior descending and left circumflex to produce a >50% narrowing of the coronary lumen. We analyse and characterise haemodynamic effects caused by each type of plaque. Computational fluid dynamics was performed to simulate realistic physiological conditions that reveal the in vivo cardiac haemodynamics. Velocity, wall shear stress (WSS) and pressure gradient (PSG) in the left coronary artery were calculated and compared in all plaque configurations during cardiac cycles.Results: Our results showed that the highest velocity and PSG were found in the type of plaque configuration which involved all of the three left coronary branches. Plaques located in the left circumflex branch resulted in highly significant changes of the velocity, WSS and PSG (p