In vivo functional connectome of human brainstem nuclei of the ascending arousal, autonomic, and motor systems by high spatial resolution 7-Tesla fMRI
In vivo functional connectome of human brainstem nuclei of the ascending arousal, autonomic, and motor systems by high spatial resolution 7-Tesla fMRI
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DOI：
10.1007/s10334-016-0546-3
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发表时间：
2016-06-01
影响因子：
2.3
通讯作者：
Wald, Lawrence L.
中科院分区：
文献类型：
--
作者：
Bianciardi, Marta;Toschi, Nicola;Wald, Lawrence L.
我们的目的是通过使用种子相关的超高磁场功能磁共振成像（fMRI）数据映射在体内人类的几个脑干核团与大脑的其他部分的功能连接。我们使用最近开发的模板的11个脑干核团来自多对比结构MRI在7特斯拉作为种子区域，以确定它们与大脑的其他部分的连接。为了实现这一点，我们使用了7特斯拉功能磁共振成像与3特斯拉相比增加的对比度噪声比和时间效率高的同步多切片成像，以高空间分辨率覆盖大脑（1.1 mm各向同性标称分辨率），同时保持短重复时间（2.5秒）.描绘的皮尔逊相关性为基础的功能连接图在现有的组织学和动物实验的背景下，对12个对照组的11个脑干上升唤醒、运动和自主神经系统的神经核团（连接体）进行了介绍和讨论。考虑到所研究的脑干核团在几种重要功能中起着至关重要的作用，所描绘的初步连接体可能被证明对人类脑干功能和病理学的未来体内研究和临床研究有用，包括意识障碍、睡眠障碍、自主神经障碍、帕金森病和其他运动障碍。
Our aim was to map the in vivo human functional connectivity of several brainstem nuclei with the rest of the brain by using seed-based correlation of ultra-high magnetic field functional magnetic resonance imaging (fMRI) data.We used the recently developed template of 11 brainstem nuclei derived from multi-contrast structural MRI at 7 Tesla as seed regions to determine their connectivity to the rest of the brain. To achieve this, we used the increased contrast-to-noise ratio of 7-Tesla fMRI compared with 3 Tesla and time-efficient simultaneous multi-slice imaging to cover the brain with high spatial resolution (1.1-mm isotropic nominal resolution) while maintaining a short repetition time (2.5 s).The delineated Pearson's correlation-based functional connectivity diagrams (connectomes) of 11 brainstem nuclei of the ascending arousal, motor, and autonomic systems from 12 controls are presented and discussed in the context of existing histology and animal work.Considering that the investigated brainstem nuclei play a crucial role in several vital functions, the delineated preliminary connectomes might prove useful for future in vivo research and clinical studies of human brainstem function and pathology, including disorders of consciousness, sleep disorders, autonomic disorders, Parkinson's disease, and other motor disorders.