Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women.
Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women.
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DOI：
10.1038/gene.2015.13
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发表时间：
2015-07
影响因子：
5
通讯作者：
Partners in Prevention HSV/HIV Transmission Study Team
中科院分区：
文献类型：
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作者：
Mackelprang RD;Scoville CW;Cohen CR;Ondondo RO;Bigham AW;Celum C;Campbell MS;Essex M;Wald A;Kiarie J;Ronald A;Gray G;Lingappa JR;Partners in Prevention HSV/HIV Transmission Study Team
细菌性阴道病（BV）是一种常见的阴道综合征，与微生物群改变有关，增加了早产和获得性传播疾病的风险。虽然toll样受体（TLRs）是先天免疫反应的核心，但BV的病因尚不清楚。我们评估了HIV-1感染和未感染的非洲妇女中TLR snp与BV之间的关系。采用Logistic回归评估TLRs 2- 4,7 -9中SNPs （N=99）与BV（按Nugent标准分类）之间的关系。在HIV-1未感染的女性中，TLR7 rss5743737和TLR7 rs1634323与BV风险降低相关，而TLR7 rs179012与风险增加相关。TLR2 SNP rs3804099与HIV-1感染女性感染BV的风险降低相关。我们的研究结果表明，在HIV-1感染和HIV-1未感染的妇女中，TLR与BV的关联可能存在差异。
Bacterial vaginosis (BV) is a common vaginal syndrome associated with altered microflora that increases the risk of preterm delivery and acquisition of sexually transmitted diseases. The cause of BV is unknown although toll-like receptors (TLRs), that are central to innate immune responses, may be important. We evaluated associations between TLR SNPs and BV among HIV-1 infected and uninfected African women. Logistic regression was used to assess associations between SNPs (N=99) in TLRs 2-4, 7-9 and BV (as classified by Nugent's criteria). Among HIV-1 uninfected women, TLR7 rs5743737 and TLR7 rs1634323 were associated with a decreased risk of BV while TLR7 rs179012 was associated with an increased risk. TLR2 SNP rs3804099 was associated with a decreased risk of BV among HIV-1 infected women. Our findings indicate that there may be differences in TLR association with BV among HIV-1 infected and HIV-1 uninfected women.