Valence Dependent Asymmetric Release of Norepinephrine in the Basolateral Amygdala
Valence Dependent Asymmetric Release of Norepinephrine in the Basolateral Amygdala
复制标题
DOI：
10.1037/a0020885
复制
发表时间：
2010-10-01
影响因子：
1.9
通讯作者：
Williams, Cedric L.
中科院分区：
文献类型：
--
作者：
Young, Erica J.;Williams, Cedric L.
来自人类文献的新证据表明，充满情感的环境刺激的效价可能决定杏仁核激活是否在一个半球相对于对侧更大。然而，只有很少的动物研究试图解开潜在的机制，选择性，价，价本研究评估了暴露于积极或消极的食欲刺激是否会引起对侧大脑半球杏仁核活动的依赖性启动。操作性学习任务中的条件对左杏仁核与右杏仁核的去甲肾上腺素激活的影响不同。分别从雄性道利大鼠的基底外侧核收集去甲肾上腺素的透析液样品。在训练条件下对去甲肾上腺素活性的波动进行取样，包括突然转变E。增加或减少）在随后的研究中，去甲肾上腺素的透析液样品在治疗前，治疗期间，在巴甫洛夫恐惧条件反射过程中，在呈现涉及足底电击递送的负效价刺激后，在呈现意外增加的积极体验的组中，左侧而不是右侧基底外侧杏仁核中的去甲肾上腺素浓度升高。压杆后的食物奖励（p <0.01），相对于各自的对照相比，暴露于负效价的事件，包括在恐惧条件反射过程中按杆或电击脚后预期食物倒回的减少，导致仅从右侧而不是左侧基底外侧杏仁核取样的去甲肾上腺素输出显着增加。这些发现表明，学习事件的效价在启动过程中是选择性的。基底外侧杏仁核的不对称激活
Emerging evidence from literature on humans suggests the valence of emotionally laden environmental stimuli may dictate whether amygdala activation is greater in one hemisphere relative to the contralateral side However, only a paucity of animal studies attempt to unravel the mechanisms underlying, the selective, valence-dependent initiation of activity in the amyadala of opposing hemispheres The present studies assessed whether exposure to positive or negative appetitive conditions in an operant learning task differentially impacts norepinephrine activation of the left versus right amygdala. respectively Dialysate samples of norepinephrine were collected from the basolateral nucleus of male Sprague Dawley rats Fluctuations in norepinephrine activity were sampled during training conditions involving an abrupt shift e. increase or decrease) in the magnitude of food rewards normally provided for bar press responses In a subsequent study, dialysate samples of norepinephrine were collected before, during, and after presentation of a negatively valenced stimulus involving footshock delivery during Pavlovian fear conditioning Norepinephrine concentrations in the left but not right basolateral amygdala were elevated in groups presented with a positive experience of an unexpected increase in food reward after bar pressing (p < 01), relative to respective controls In contrast, exposure to negatively valenced events involving a reduction in expected food rewinds after bar pressing or presentation of a footshock during fear conditioning produced significant increases in norepinephrine output sampled from only the right but not left basolateral amygdala These findings demonstrate that the valence of a learning event is selective in initiating asymmetric activation of the basolateral amygdala