Effect of pregnenolone-16alpha-carbonitrile on the rat liver.
Effect of pregnenolone-16alpha-carbonitrile on the rat liver.
复制标题
孕烯醇酮-16α-甲腈对大鼠肝脏的影响。
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
H. Selye
中科院分区：
文献类型：
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作者：
P. Kourounakis;S. Szabó;H. Selye
在雌性大鼠中，双烯醇酮-16 α-腈[PCN（一种已知的微粒体酶诱导剂）]增加了肝脏重量，并显著增加了肝脏蛋白、总脂质、磷脂和ATP浓度。这些变化与肝脏药物代谢酶诱导有关。PCN不会改变体重或肝脏中的水、灰分、甘油三酯和胆固醇水平，但会导致肝糖原轻度减少。
In female rats, pregnenolone-16alpha-carbonitrile [PCN (a known microsomal enzyme inducer)] augmented liver weight and significantly increased hepatic protein, total lipid, phospholipid and ATP concentrations. These changes were correlated with hepatic drug-metabolizing enzyme induction. PCN did not alter body weight, or water, ash, triglyceride and cholesterol levels in the liver, but caused a mild reduction of hepatic glycogen.