RECOMBINATION NODULES AND SYNAPTONEMAL COMPLEX IN RECOMBINATION-DEFECTIVE FEMALES OF DROSOPHILA-MELANOGASTER
RECOMBINATION NODULES AND SYNAPTONEMAL COMPLEX IN RECOMBINATION-DEFECTIVE FEMALES OF DROSOPHILA-MELANOGASTER
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DOI：
10.1007/bf00293472
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发表时间：
1979-01-01
期刊：
影响因子：
1.6
通讯作者：
CARPENTER, ATC
中科院分区：
文献类型：
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作者：
CARPENTER, ATC
通过电镜检测了mei-9、mei-218和mei-41位点突变等位基因在I前期的细胞学效应。这些突变均不影响突触复合体的结构、连续性或时间行为。条件缺陷突变体mei-218和mei-41均影响球形重组结节的数量和形态，且至少影响椭球形重组结节的数量，而交换缺陷突变体mei-9的椭球形和球形重组结节的数量和形态均正常。mei-218和mei-41对减数分裂重组和重组结节的平行作用表明，球形重组结节至少标志着交换事件的发生位置；这些突变体对结核形态的影响表明，结核在重组过程中发挥了积极作用。mei-9的结节表型表明，在重组事件结束阶段之前，存在球形结节，并且可能功能良好。这3个突变体对椭球和球形结节的平行作用表明它们是相关的结构，但没有阐明这种关系的本质。减数分裂重组的各个方面都可能受到重组结节的影响。
The cytological effects of mutant alleles of the mei-9, mei-218 and mei-41 loci during prophase I were examined by EM. None of these mutants affect synaptonemal complex structure, continuity or temporal behavior. Both the precondition-defective mutants mei-218 and mei-41 affect number and morphology of spherical recombination nodules and apparently affect at least the numbers of ellipsoidal recombination nodules, whereas in the exchange-defective mutant mei-9 the numbers and morphologies of both ellipsoidal and spherical recombination nodules are normal. The parallel effects of mei-218 and mei-41 on meiotic recombination and on recombination nodules indicate that spherical recombination nodules at least mark the site of exchange events; the effects of these mutants on nodule morphology suggest that the nodule performs an active role in the recombination process. The nodule phenotype of mei-9 indicates that spherical nodules are present and presumably functioning well before the concluding stages of the recombination event. The parallel effects of all 3 mutants on ellipsoidal and spherical nodules indicate that these are related structures but does not elucidate the nature of the relationship. All aspects of meiotic recombination may be under the influence of recombination nodules.