The mechanism of accommodation in primates
The mechanism of accommodation in primates
复制标题
DOI：
10.1016/s0161-6420(99)00502-3
复制
发表时间：
1999-05-01
期刊：
影响因子：
13.7
通讯作者：
Kaufman, PL
中科院分区：
文献类型：
--
作者：
Glasser, A;Kaufman, PL
目的：根据最近提出的灵长类动物中的新的矫正机制和伴随的用于逆转老花眼的有争议的外科手术，使用猴研究灵长类动物中的矫正机制，设计：实验研究，方法：通过手术植入中脑的电极刺激和局部眼部应用毒蕈碱激动剂诱导调节，通过局部应用毒蕈碱拮抗剂实现药理学失适应。利用超声生物显微镜和房角影像学对调节和失调节过程中透镜赤道和睫状体的运动进行成像，并对图像进行分析以确定运动的方向和程度。尽管电刺激会发生系统性眼球运动，而药物刺激会发生非系统性眼球运动，在所有情况下，睫状体和透镜赤道在调节过程中远离巩膜。结论：睫状体结构的运动与Helmholtz描述的经典调节机制一致，而与Schachar最近提出的调节机制相反。
Objective: To study the accommodative mechanism in primates using monkeys, in light of a recently proposed novel accommodative mechanism in primates and a concomitant controversial surgical procedure for the reversal of presbyopia,Design: Experimental study,Methods: Accommodation was induced by stimulation of an electrode surgically implanted in the midbrain and by topical ocular application of muscarinic agonists, Pharmacologic disaccommodation was achieved by topical application of a muscarinic antagonist. Movements of the lens equator and the ciliary body were imaged during accommodation and disaccommodation using ultrasound biomicroscopy and goniovideography, and the images were analyzed to determine the direction and the extent of the movements.Results: Despite the systematic eye movements occurring with electrical stimulation and the nonsystematic eye movements occurring with pharmacologic stimulation, in all instances the ciliary body and the lens equator moved away from the sclera during accommodation.Conclusions: Movement of the accommodative structures is consistent with the classic mechanism of accommodation described by Helmholtz, and contrary to that recently proposed by Schachar.