Computer-based cognitive training for mild cognitive impairment: results from a pilot randomized, controlled trial.
Computer-based cognitive training for mild cognitive impairment: results from a pilot randomized, controlled trial.
复制标题
DOI：
10.1097/wad.0b013e31819c6137
复制
发表时间：
2009-07
影响因子：
2.1
通讯作者：
Kramer JH
中科院分区：
文献类型：
--
作者：
Barnes DE;Yaffe K;Belfor N;Jagust WJ;DeCarli C;Reed BR;Kramer JH
我们对47名轻度认知障碍（MCI）受试者进行了一项密集的、基于计算机的认知训练的初步随机对照试验。干预组进行专门设计的练习，以提高听觉处理速度和准确性，每天100分钟，每周5天，持续6周;对照组进行更多的被动计算机活动（阅读，听力，视觉空间游戏），时间相似。受试者平均年龄为74岁，60%为男性; 77%成功完成培训。在我们的主要结局中，干预组的神经心理状态评估可重复成套测验（RBANS）总分提高了0.36标准差（SD）（p=0.097），而对照组为0.03 SD（p=0.88），两组之间的差异不显著，为0.33 SD（p=0.26）。在12个次要结局指标上，组间大多数差异无统计学意义。然而，我们观察到一种模式，其中言语学习和记忆措施的效果大小倾向于有利于干预组，而语言和视觉空间功能措施的效果大小倾向于有利于对照组，这提高了这些培训计划可能具有特定领域的影响的可能性。我们的结论是，密集的，基于计算机的心理活动是可行的MCI的主题，更大的试验是必要的。
We performed a pilot randomized, controlled trial of intensive, computer-based cognitive training in 47 subjects with mild cognitive impairment (MCI). The intervention group performed exercises specifically designed to improve auditory processing speed and accuracy for 100 minutes/day, 5 days/week for 6 weeks; the control group performed more passive computer activities (reading, listening, visuospatial game) for similar amounts of time. Subjects had a mean age of 74 years and 60% were men; 77% successfully completed training. On our primary outcome, Repeatable Battery for Assessment of Neuropsychological Status (RBANS) total scores improved 0.36 standard deviations (SD) in the intervention group (p=0.097) compared to 0.03 SD in the control group (p=0.88) for a non-significant difference between the groups of 0.33 SD (p=0.26). On 12 secondary outcome measures, most differences between the groups were not statistically significant. However, we observed a pattern in which effect sizes for verbal learning and memory measures tended to favor the intervention group while effect sizes for language and visuospatial function measures tended to favor the control group, which raises the possibility that these training programs may have domain-specific effects. We conclude that intensive, computer-based mental activity is feasible in subjects with MCI and that larger trials are warranted.