Specificity of abnormal brain volume in major depressive disorder: A comparison with borderline personality disorder
Specificity of abnormal brain volume in major depressive disorder: A comparison with borderline personality disorder
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DOI：
10.1016/j.jad.2014.11.059
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发表时间：
2015-03-15
影响因子：
6.6
通讯作者：
Wolf, R. Christian
中科院分区：
文献类型：
--
作者：
Depping, Malte S.;Wolf, Nadine D.;Wolf, R. Christian
背景：脑容量异常在重性抑郁症（MDD）中经常被证实。目前还不清楚这些发现是否是MDD的特异性，因为异常的大脑结构也存在于抑郁共病和情感失调的障碍中，如边缘型人格障碍（BPD）。在这项跨诊断研究中，我们的目的是调查是否区域脑容量损失区分MDD和BPD。此外，我们测试脑容量和临床变量之间的关联内和诊断groups.Methods：22女性与DSM-IV诊断的MDD，17女性与DSM-IV诊断的BPD和没有共病的创伤后应激障碍，和22年龄匹配的女性健康对照（HC）进行了调查，使用磁共振成像。高分辨率的结构数据进行了分析，使用基于体素的morphometry.Results：一个显着的（p < 0.05，集群校正）的前扣带皮层（ACC）的体积减少，发现在MDD相比HC，而不是体积减少的杏仁核在BPD相比，HC和MDD。区域灰质体积诊断MDD的敏感性和特异性为中等至中等。杏仁核体积与抑郁症状在整个patient sample.Limitations：本研究的潜在局限性包括适度的样本量和异质性精神药物treatment.Conclusions：ACC体积减少是更明显的MDD与中等程度的体积损失在BPD相比，HC。相比之下，杏仁核体积损失在BPD中比MDD更明显，但杏仁核体积与两种疾病的情感症状表达相关。(C)2014爱思唯尔有限公司版权所有。
Background: Abnormal brain volume has been frequently demonstrated in major depressive disorder (MDD). It is unclear if these findings are specific for MDD since aberrant brain structure is also present in disorders with depressive comorbidity and affective dysregulation, such as borderline personality disorder (BPD). In this transdiagnostic study, we aimed to investigate if regional brain volume loss differentiates between MDD and BPD. Further, we tested for associations between brain volume and clinical variables within and between diagnostic groups.Methods: 22 Females with a DSM-IV diagnosis of MDD, 17 females with a DSM-IV diagnosis of BPD and without comorbid posttraumatic stress disorder, and 22 age-matched female healthy controls (HC) were investigated using magnetic resonance imaging. High-resolution structural data were analyzed using voxel-based morphometry.Results: A significant (p < 0.05, cluster-corrected) volume decrease of the anterior cingulate cortex (ACC) was found in MDD compared to HC, as opposed to volume decreases of the amygdala in BPD compared to both HC and MDD. Sensitivity and specificity of regional gray matter volume for a diagnosis of MDD were modest to fair. Amygdala volume was related to depressive symptoms across the entire patient sample.Limitations: Potential limitations of this study include the modest sample size and the heterogeneous psychotropic drug treatment.Conclusions: ACC volume reduction is more pronounced in MDD with an intermediate degree of volume loss in BPD compared to HC. In contrast, amygdala volume loss is more pronounced in BPD compared to MDD, yet amygdala volume is associated with affective symptom expression in both disorders. (C) 2014 Elsevier B.V. All rights reserved.