The complement of enzymatic sets in different species
The complement of enzymatic sets in different species
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DOI：
10.1016/j.jmb.2005.04.027
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发表时间：
2005-06-17
影响因子：
5.6
通讯作者：
Thornton, JM
中科院分区：
文献类型：
--
作者：
Freilich, S;Spriggs, RV;Thornton, JM
我们在这里提出了一个全面的分析，在各种各样的物种的酶的补充。由于酶是一个相对保守的组，有几个分类系统是共同的所有物种和链接的蛋白质序列的酶功能。因此，酶是研究序列扩增、功能分化和表型变化之间关系的理想功能基团。通过使用从注释良好的SWISS-PROT数据库检索的信息，以及来自各种完全测序的基因组的序列信息和来自EC功能方案的信息，我们在这里的目的是估计基因组中的酶的分数，以确定它们在不同生活领域的功能冗余的程度，并确定后生动物中的功能创新和谱系特异性扩展。脉我们发现，原核生物和真核生物物种的不同，在其基因组中的酶的分数和在其酶集的扩展模式。我们观察到的功能冗余的增加伴随着物种复杂性的增加。进行定量评估，以确定不同物种的功能冗余程度。最后，我们报告了一个大规模的扩张，在哺乳动物的酶参与信号和降解。(c)2005爱思唯尔有限公司保留所有权利。
We present here a comprehensive analysis of the complement of enzymes in a large variety of species. As enzymes are a relatively conserved group there are several classification systems available that are common to all species and link a protein sequence to an enzymatic function. Enzymes are therefore an ideal functional group to study the relationship between sequence expansion, functional divergence and phenotypic changes. By using information retrieved from the well annotated SWISS-PROT database together with sequence information from a variety of fully sequenced genomes and information from the EC functional scheme we have aimed here to estimate the fraction of enzymes in genomes, to determine the extent of their functional redundancy in different domains of life and to identify functional innovations and lineage specific expansions in the metazoa. lineage. We found that prokaryote and eukaryote species differ both in the fraction of enzymes in their genomes and in the pattern of expansion of their enzymatic sets. We observe an increase in functional redundancy accompanying an increase in species complexity. A quantitative assessment was performed in order to determine the degree of functional redundancy in different species. Finally, we report a massive expansion in the number of mammalian enzymes involved in signalling and degradation. (c) 2005 Elsevier Ltd. All rights reserved.