Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway
Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway
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DOI：
10.1016/j.jacbts.2019.06.005
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发表时间：
2019-10-01
影响因子：
9.7
通讯作者：
Legrand, Matthieu
中科院分区：
文献类型：
--
作者：
Prud'homme, Mathilde;Coutrot, Maxime;Legrand, Matthieu
急性肾损伤与心力衰竭和死亡率增加有关。本研究表明，急性肾损伤通过门凝集素-3 （Gal-3）依赖性途径诱导远端心功能障碍、损伤、损伤和纤维化。Gal-3来源于骨髓来源的免疫细胞。通过阻断这一途径可以预防心脏损伤。(C) 2019作者。由爱思唯尔代表美国心脏病学会基金会出版。
Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a gatectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells. Cardiac damage could be prevented by blocking this pathway. (C) 2019 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.