Role of Medial Prefrontal Cortex Serotonin 2A Receptors in the Control of Retrieval of Recognition Memory in Rats
Role of Medial Prefrontal Cortex Serotonin 2A Receptors in the Control of Retrieval of Recognition Memory in Rats
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DOI：
10.1523/jneurosci.2087-13.2013
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发表时间：
2013-10-02
影响因子：
5.3
通讯作者：
Weisstaub, Noelia
中科院分区：
文献类型：
--
作者：
Bekinschtein, Pedro;Constanza Renner, Maria;Weisstaub, Noelia
通常，提取线索并不是唯一地与一个特定的记忆相关，这可能导致记忆干扰。在情景记忆提取或在时空背景下记忆特定事件时，控制干扰尤为重要。尽管在人类研究中，前额叶皮层（PFC）参与情景记忆，但有关PFC参与记忆的机制和神经递质系统的信息很少。虽然多巴胺能系统与PFC功能和调节有关，但其在记忆处理中的作用知之甚少。我们推测PFC中的胆碱能系统，特别是5-HT 2A受体（5-HT 2AR）可能在记忆提取的控制中起作用。在这项工作中，我们使用了不同版本的物体识别任务在大鼠的内侧PFC（mPFC）的多巴胺能调制在记忆提取中的作用。我们发现，5-HT 2AR在mPFC的封锁影响检索的对象在上下文记忆中的一个自发的新奇偏好任务，同时保留单一项目的识别记忆。我们还确定，5-HT 2ARs在mPFC是必需的海马-mPFC相互作用在检索这种类型的记忆，这表明mPFC控制存储在海马中的记忆痕迹的表达偏检索到最相关的。
Often, retrieval cues are not uniquely related to one specific memory, which could lead to memory interference. Controlling interference is particularly important during episodic memory retrieval or when remembering specific events in a spatiotemporal context. Despite a clear involvement of prefrontal cortex (PFC) in episodic memory in human studies, information regarding the mechanisms and neurotransmitter systems in PFC involved in memory is scarce. Although the serotoninergic system has been linked to PFC functionality and modulation, its role in memory processing is poorly understood. We hypothesized that the serotoninergic system in PFC, in particular the 5-HT2A receptor (5-HT2AR) could have a role in the control of memory retrieval. In this work we used different versions of the object recognition task in rats to study the role of the serotoninergic modulation in the medial PFC (mPFC) in memory retrieval. We found that blockade of 5-HT2AR in mPFC affects retrieval of an object in context memory in a spontaneous novelty preference task, while sparing single-item recognition memory. We also determined that 5-HT2ARs in mPFC are required for hippocampal-mPFC interaction during retrieval of this type of memory, suggesting that the mPFC controls the expression of memory traces stored in the hippocampus biasing retrieval to the most relevant one.