HEPATOBLASTOMA PRODUCING BOTH ALPHA-FETOPROTEIN AND HUMAN CHORIONIC-GONADOTROPIN - CLINICOPATHOLOGIC ANALYSIS OF 4 CASES AND A REVIEW OF THE LITERATURE
HEPATOBLASTOMA PRODUCING BOTH ALPHA-FETOPROTEIN AND HUMAN CHORIONIC-GONADOTROPIN - CLINICOPATHOLOGIC ANALYSIS OF 4 CASES AND A REVIEW OF THE LITERATURE
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DOI：
10.1002/1097-0142(19851001)56:7
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发表时间：
1985-01-01
期刊：
影响因子：
6.2
通讯作者：
SAWADA, T
中科院分区：
文献类型：
--
作者：
NAKAGAWARA, A;IKEDA, K;SAWADA, T
本文对4例肝母细胞瘤伴性早熟进行了临床病理分析，并对文献报道的21例肝母细胞瘤伴性早熟进行了分析。所有4名患者均为男性，年龄从11个月至35个月不等。术后12个月内死亡3例，存活1例。在组织学上，所有患者都有肝母细胞瘤，胎儿和胚胎型细胞共存，尽管其中两个主要是胎儿细胞，另两个主要是胚胎细胞。肿瘤巨细胞在所有这些情况下很少遇到。在我们的四个病例和文献报道的其他五个病例中，血清或尿液中的甲胎蛋白（AFP）和人绒毛膜促性腺激素（hCG）均升高。虽然血清AFP水平与临床症状的严重程度有关，但血或尿hCG水平与临床病程并不一定相符。这些预后不良的男性化肝母细胞瘤可能从不同的细胞分泌两种不同的肿瘤标志物AFP和hCG，并且这些功能性肿瘤细胞可能并不总是同时存在于复发或转移性肿瘤中。
A clinicopathologic study was done of four cases of hepatoblastoma with precocious puberty, together with an analysis of 21 such cases reported in the literature. All four patients were males, the age ranging from 11 to 35 months. Three of the four patients died within 12 months after operation, but the fourth is living. Histologically, all patients had a hepatoblastoma with the coexistence of both fetal and embryonal type cells, although predominantly fetal in two and predominantly embryonal in the other two. Tumor giant cells were rarely encountered in all these cases. Both alpha-fetoprotein (AFP) and human chorionic gonadotropin (hCG) in the serum or urine increased in our four cases and in five other cases reported in the literature. Though the serum AFP level paralleled the severity of clinical symptoms, the serum or urine hCG did not necessarily correspond to the clinical course. It is likely that these poorly prognostic virilizing hepatoblastomas secrete two different tumor markers, AFP and hCG, from different cells, and that these functioning tumor cells may not always exist concurrently in the recurrent or metastatic tumor.