Palladium-Catalyzed Glycosylation: Novel Synthetic Approach to Diverse N-Heterocyclic Glycosides
Palladium-Catalyzed Glycosylation: Novel Synthetic Approach to Diverse N-Heterocyclic Glycosides
复制标题
DOI：
10.1021/ol5037437
复制
发表时间：
2015-03-20
期刊：
影响因子：
5.2
通讯作者：
Liu, Xue-Wei
中科院分区：
文献类型：
--
作者：
Ji, Li;Xiang, Shao-Hua;Liu, Xue-Wei
报道了一种高效且高度立体选择性的构建N-杂环苷的方法。该方法基于钯催化的烯丙基化反应，其以良好至优异的产率和β-或α-选择性提供N-杂环糖基化合物。各种N-亲核试剂进行了检查，这个反应和选择的N-糖基靛红底物进一步阐述了双吲哚糖，有潜力作为抗增殖药物。
An efficient and highly stereoselective method for the construction of N-heterocyclic glycosides is reported. This method is based on a palladium-catalyzed allylation which proceeded to provide N-heterocyclic glycosyl compounds in good-to-excellent yields with beta- or alpha-selectivity. Various N-nucleophiles were examined for this reaction and selected N-glycosyl isatin substrates were further elaborated to bis-indole sugars which have potential as antiproliferative drugs.