Human Leukocyte Antigen (HLA) Class I Susceptible Alleles Against COVID-19 Increase Both Infection and Severity Rate.
Human Leukocyte Antigen (HLA) Class I Susceptible Alleles Against COVID-19 Increase Both Infection and Severity Rate.
复制标题
DOI：
10.7759/cureus.12239
复制
发表时间：
2020-12-23
期刊：
影响因子：
--
通讯作者：
Ishii T
中科院分区：
文献类型：
--
作者：
Ishii T
各国严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）严重程度的差异可能与影响细胞毒性T淋巴细胞（CTL）反应性的人类白细胞抗原（HLA） I类分子的差异有关。方法为明确HLA I类等位基因与SARS-CoV-2多肽结合谱及各国HLA-A、-B和-A/B单倍型等位基因频率，分析HLA I类等位基因与SARS-CoV-2严重程度的关系。结果HLA-A1与各国每百万人口死亡人数（严重率）呈指数近似相关，相关系数R=0.4879。此外，每百万感染病例（感染率）与严重程度率之间的相关性线性近似，R=0.7422。HLA-A弱等位基因库小于300时，与严重程度呈指数近似（R=0.5972），与感染率呈线性近似（R=0.6808）。弱HLA-B等位基因30个及以下与严重程度无相关性（R=-0.1530）。弱HLA-A/B单倍型比单独弱HLA-A对严重率的影响更大。因此，我们计算了简单的HLA I类易感性指数，得到了指数近似与严重程度的强相关性（R=0.7388）。结论HLA I类易感等位基因可增加COVID-19的感染率和严重程度。弱HLA-A是严重程度的主要影响因素，而单独弱hla -B无相关性。然而，弱HLA-A/B单倍型对严重率的影响比单独的弱-A更强。
Introduction Each country's difference in the severity rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be explained by the difference in human leukocyte antigen (HLA) class I molecules, which affects the reactivity of cytotoxic T lymphocyte (CTL). Methods To clarify the relationship between HLA class I and the severity rate, the binding repertoires of each HLA class I allele to SARS-CoV-2 peptides and the allele frequencies of HLA-A, -B, and -A/B haplotypes in each country were quoted. Results HLA-A1 and the number of deaths per million population (severity rate) in each country had an exponential approximation correlation with correlation coefficient R=0.4879. In addition, the correlation between the infected cases per million (infection rate) and the severity rate was linearly approximated, with R=0.7422. Weak HLA-A alleles with a repertoire of under 300 also had an exponential approximation correlation with the severity rate (R=0.5972), whereas there was a linear approximation with the infection rate (R=0.6808). Weak HLA-B alleles of 30 repertoires or less had no correlation with the severity rate (R=-0.1530). The weak HLA-A/B haplotype has a stronger effect on the severity rate than the weak HLA-A alone. Therefore, the simple HLA class I susceptibility index was calculated, and a strong correlation (R=0.7388) of an exponential approximation with the severity rate was obtained. Conclusions HLA class I susceptible alleles against COVID-19 increase both infection and severity rate. The weak HLA-A is a major factor of severity rate, whereas the weak -B alone has no correlation. However, the weak HLA-A/B haplotype has a stronger effect on the severity rate than the weak -A alone.