The fitness of drug-resistant malaria parasites in a rodent model: multiplicity of infection
The fitness of drug-resistant malaria parasites in a rodent model: multiplicity of infection
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DOI：
10.1111/j.1420-9101.2011.02369.x
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发表时间：
2011-11-01
影响因子：
2.1
通讯作者：
Read, A. F.
中科院分区：
文献类型：
--
作者：
Huijben, S.;Sim, D. G.;Read, A. F.
疟疾感染通常由一个以上的克隆复制谱系组成。敏感和耐药寄生虫之间的宿主内相互作用可以对耐药性的演变产生深远的影响。在这里，使用疟原虫chabaudi小鼠疟疾模型，我们问的阻力的成本和收益是否受到与耐药克隆竞争的共感染菌株的数量的影响。我们发现，在未经治疗的感染和显着的竞争性释放治疗后的耐药寄生虫的强烈竞争性抑制。竞争抑制的程度取决于竞争者的身份。然而，有没有整体效应的多样性的易感寄生虫的竞争性抑制或释放的程度。如果这些发现具有普遍性，那么传播强度将影响抗性进化，因为它影响混合感染的频率，而不是因为它影响每个宿主的克隆分布。这将大大简化计算问题，充分捕捉宿主内的生态模型中的耐药性演变的疟疾。
Malaria infections normally consist of more than one clonally replicating lineage. Within-host interactions between sensitive and resistant parasites can have profound effects on the evolution of drug resistance. Here, using the Plasmodium chabaudi mouse malaria model, we ask whether the costs and benefits of resistance are affected by the number of co-infecting strains competing with a resistant clone. We found strong competitive suppression of resistant parasites in untreated infections and marked competitive release following treatment. The magnitude of competitive suppression depended on competitor identity. However, there was no overall effect of the diversity of susceptible parasites on the extent of competitive suppression or release. If these findings generalize, then transmission intensity will impact on resistance evolution because of its effect on the frequency of mixed infections, not because of its effect on the distribution of clones per host. This would greatly simplify the computational problems of adequately capturing within-host ecology in models of drug resistance evolution in malaria.