Mirror-symmetric tonotopic maps in human primary auditory cortex
Mirror-symmetric tonotopic maps in human primary auditory cortex
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DOI：
10.1016/s0896-6273(03)00669-x
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发表时间：
2003-11-13
期刊：
影响因子：
16.2
通讯作者：
Goebel, R
中科院分区：
文献类型：
--
作者：
Formisano, E;Kim, DS;Goebel, R
了解人类初级听觉皮层（PAC）的功能组织是阐明声音（包括语音和音乐）感知的神经机制的重要步骤。基于对动物的侵入性研究，认为人类PAC中的神经元相对于声音的频谱内容选择性地响应，形成一个或多个图，其中皮层表面上的相邻块响应于相似的频率（音调分布图）。然而，人类大脑中这种音调分布图的数量和皮层布局仍然未知。在这里，我们使用沉默，事件相关的功能磁共振成像在7特斯拉和基于皮质的功能数据分析，以高空间分辨率描绘的详细地形图的两个tonotopic地图在两个相邻的分区PAC。这些地图共享一个低频边界，镜像对称，显然类似于那些推测同源领域的猕猴。
Understanding the functional organization of the human primary auditory cortex (PAC) is an essential step in elucidating the neural mechanisms underlying the perception of sound, including speech and music. Based on invasive research in animals, it is believed that neurons in human PAC that respond selectively with respect to the spectral content of a sound form one or more maps in which neighboring patches on the cortical surface respond to similar frequencies (tonotopic maps). The number and the cortical layout of such tonotopic maps in the human brain, however, remain unknown. Here we use silent, event-related functional magnetic resonance imaging at 7 Tesla and a cortex-based analysis of functional data to delineate with high spatial resolution the detailed topography of two tonotopic maps in two adjacent subdivisions of PAC. These maps share a low-frequency border, are mirror symmetric, and clearly resemble those of presumably homologous fields in the macaque monkey.