Clinical subtypes of lone atrial fibrillation
Clinical subtypes of lone atrial fibrillation
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DOI：
10.1111/j.1540-8159.2005.00161.x
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发表时间：
2005-07-01
影响因子：
1.8
通讯作者：
Ellinor, PT
中科院分区：
文献类型：
--
作者：
Patton, KK;Zacks, ES;Ellinor, PT
目的：在面对越来越多的证据，潜在的遗传异质性孤立性心房颤动（LAF），我们进行了临床分析的受试者，以确定该arrhythmia.Methods和Results的表型子集：我们评估了一系列患者谁提出与LAF之间的2001年7月5日和2003年12月19日。受试者接受标准化访谈，以了解详细的病史、既往治疗和房颤诱因。审查了体格检查、心电图和超声心动图的结果。入组了180例诊断时平均年龄为45岁（15-67岁）的受试者。大多数患者最初表现为阵发性房颤（94%），7.8%进展为永久性房颤。报告的房颤触发因素包括睡眠（44%）、运动（36%）、饮酒（36%）和进食（34%）。LAF女性患者有明显的症状，是阵发性AF的触发因素，超过四分之一的患者有潜在的风湿性疾病。AF的几个子集，包括家族性AF（39%），运动诱发的AF（32%），传导系统疾病需要起搏器植入（7%），被identified.Conclusions：家族史，运动作为AF的触发器，和历史的起搏器确定LAF亚型。
Aims: In the face of increasing evidence of underlying genetic heterogeneity for lone atrial fibrillation (LAF), we undertook a clinical analysis of subjects to identify the phenotypic subsets of this arrhythmia.Methods and Results: We evaluated serial patients who presented with LAF between July 5, 2001 and December 19, 2003. Subjects underwent a standardized interview to elicit a detailed medical history, prior therapies, and precipitants of atrial fibrillation. The results of a physical exam, electrocardiogram and echocardiogram were reviewed. One hundred and eighty subjects with a mean age of 45 years (15-67 years) at the time of diagnosis were enrolled. The majority of patients originally presented with paroxysmal fibrillation (94%), and 7.8% progressed to permanent AF. Reported triggers for AF included sleeping (44%), exercise (36%), alcohol use (36%), and eating (34%). Women with LAF had distinct symptoms, triggers for episodic AF, and over one-fourth had an underlying rheumatologic condition. Several subsets of AF including familial AF (39%), exercise-induced AF (32%), and conduction system disease requiring pacemaker implantation (7%), were identified.Conclusions: Family history, exercise as a trigger of AF, and a history of a pacemaker identified subtypes of LAF.