Implantation and deciduoma formation after administration of antiestrogenic compounds.
Implantation and deciduoma formation after administration of antiestrogenic compounds.
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施用抗雌激素化合物后植入和蜕膜形成。
DOI：
10.1093/biolreprod/3.1.61
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发表时间：
1970
影响因子：
3.6
通讯作者：
K. Meyers
中科院分区：
文献类型：
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作者：
K. Meyers
在带有一个不育角的孕鼠中进行实验，以阐明抗雌激素化合物对蜕膜瘤形成的影响。I.C.I.的剂量在妊娠第1天或第4天给药时，使用了足以完全防止着床的46474、CN-55945-27、U-1 I100 A和U-11555 A。蜕膜瘤诱导刺激是第5天子宫内注射芝麻油或子宫内膜创伤。在没有接受抗雌激素化合物的去势孕鼠中也诱导了蜕膜瘤。在第10天测定无菌角中的蜕膜瘤反应（DR）和妊娠角中的脱落数量。在卵巢切除的孕鼠中，从第2天到第9天每天用4毫克孕酮处理，既没有着床也没有油诱导的DR发生，但子宫创伤诱导了DR;当从第4天到第9天在孕酮处理中加入1 μ g雌酮时，油诱导的DR与完整对照组相当。油诱导的，但不是创伤诱导的DR，在完整的妊娠大鼠完全抑制所有的抗雌激素化合物时，他们在第4天，而在第1天给药相同的药物防止油诱导的和创伤诱导的DR。植入均匀地防止这些化合物给药后的第1天或第4天。得出的结论是，在大鼠中，油滴注优于使用创伤诱导蜕膜瘤，因为它更接近于植入发生的条件。
Experiments were done in pregnant rats bearing one sterile cornu to clarify the effect of antiestrogenic compounds on deciduoma formation. Doses of I.C.I. 46474, CN-55945-27, U-1I100A, and U-11555A sufficient to prevent implantation completely when given on Day 1 or Day 4 of pregnancy were used. The deciduoma-inducing stimulus was either the intrauterine injection of sesame oil or traumatization of the endometrium on Day 5. Deciduomata were also induced in progesterone-treated ovariectomized pregnant rats which did not receive antiestrogenic compounds. The deciduoma response (DR) in the sterile cornu and the number of implantations in the pregnant cornu were determined on Day 10. In ovariectomized pregnant rats treated with 4 mg of progesterone daily from Days 2 to 9 neither implantation nor an oil-induced DR occurred, but uterine trauma induced a DR; when 1 �.sg of estrone was added to the progesterone treatment from Day 4 to 9 implantation and an oil-induced DR equivalent to that of intact controls were obtained. The oil-induced, but not the trauma-induced DR, in intact pregnant rats was completely inhibited by all the antiestrogenic compounds when they were given on Day 4, while administration of the same drugs on Day 1 prevented both the oil-induced and the trauma-induced DR. Implantation was uniformly prevented by these compounds after administration on either Day 1 or Day 4. It was concluded that, in the rat, oil instillation is preferable to the use of trauma for deciduoma induction, since it more closely resembles the conditions under which implantation takes place.