Effect of Education on Alzheimer's Disease-Related Neuroimaging Biomarkers in Healthy Controls, and Participants with Mild Cognitive Impairment and Alzheimer's Disease: A Cross-Sectional Study
Effect of Education on Alzheimer's Disease-Related Neuroimaging Biomarkers in Healthy Controls, and Participants with Mild Cognitive Impairment and Alzheimer's Disease: A Cross-Sectional Study
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DOI：
10.3233/jad-171168
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发表时间：
2018-01-01
影响因子：
4
通讯作者：
Nakajima, Shinichiro
中科院分区：
文献类型：
--
作者：
Wada, Masataka;Noda, Yoshihiro;Nakajima, Shinichiro
背景：认知储备是反映大脑在衰老过程中的适应性和灵活性的一种获得性能力。受教育程度被认为是影响认知储备的最重要因素之一。目的：本研究的目的是探讨受教育时间与阿尔茨海默病（AD）相关神经影像学生物标志物（例如淀粉样蛋白-β沉积、葡萄糖代谢）之间的关系。AD各个阶段的脑容量。方法：我们重新分析了阿尔茨海默病神经成像倡议的部分数据集。参与者年龄在55至90岁之间，诊断为以下之一：健康对照（HC），轻度认知障碍（MCI）或AD。采用多元回归分析研究受教育年限与β淀粉样蛋白沉积（n = 825）、脑代谢（n = 1，304）和脑容量（n = 1，606）使用F-18-Florbetapir（AV-45）成像、氟脱氧葡萄糖（FDG）正电子发射断层扫描和T1加权磁共振成像的数据。在任何组中，受教育时间与淀粉样β蛋白沉积或脑代谢无关。然而，教育的持续时间与总脑容量只有在参与者与MCI.Conclusions：我们的研究结果表明，教育可能会发挥保护作用，总脑容量在MCI阶段，但不是在HC或AD。因此，教育可能发挥重要作用，在预防痴呆的发作，通过脑储备MCI。
Background: Cognitive reserve is the acquired capacity reflecting a functional brain adaptability/flexibility in the context of aging. Educational attainment is thought to be among the most important factors that contribute to cognitive reserve.Objective: The aim of this study is to investigate the relationships among duration of education and Alzheimer's disease (AD) related neuroimaging biomarkers such as amyloid-beta deposition, glucose metabolism, and brain volumes in each stage of AD.Methods: We reanalyzed a part of the datasets of the Alzheimer's Disease Neuroimaging Initiative. Participants were between 55 and 90 years of age and diagnosed as one of the following: healthy controls (HC), mild cognitive impairment (MCI), or AD. Multiple regression analyses were conducted to examine the relationships among duration of education and amyloid-beta deposition (n = 825), brain metabolism (n = 1,304), and brain volumes (n = 1,606) among three groups using data for F-18-Florbetapir (AV-45) imaging, fludeoxyglucose (FDG) positron emission tomography, and T1-weighted magnetic resonance imaging.Results: Duration of education had no correlations with amyloid-beta deposition or brain metabolism in any groups. However, duration of education was positively associated with the total brain volume only in participants with MCI.Conclusions: Our findings suggest that education may exert a protective effect on total brain volume in the MCI stage but not in HC or AD. Thus, education may play an important role in preventing the onset of dementia through brain reserve in MCI.