Activation of mirror neuron system during gait observation in sub-acute stroke patients and healthy persons
Activation of mirror neuron system during gait observation in sub-acute stroke patients and healthy persons
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DOI：
10.1016/j.jocn.2018.09.035
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发表时间：
2019-02-01
影响因子：
2
通讯作者：
Nagahiro, Shinji
中科院分区：
文献类型：
--
作者：
Hioka, Akemi;Tada, Yoshiteru;Nagahiro, Shinji
步行的观察改善了慢性中风幸存者的步态能力。也有人认为镜像神经元系统的激活有助于这种效果。然而，尚未在亚急性中风患者中评估步态观察期间镜像神经元系统的激活。本研究的目的是阐明亚急性中风患者和健康人步态观察过程中镜像神经元系统的激活情况。在这项研究中，我们依次入组了五名接受过步态训练的亚急性脑卒中患者和九名健康人。我们使用功能磁共振成像来检测步态观察过程中的神经元激活。中风组观察期间，左侧顶下小叶、左右额下回的神经活动明显高于休息期间。健康组左侧顶下小叶、左侧额下回、左侧额中回、左侧颞上小叶和左右颞中回的神经活动明显高于休息期间。结果表明，在接受步态训练的亚急性中风患者以及健康人的步态观察过程中，镜像神经元系统被激活。我们的研究结果表明，步态观察治疗可能为经历过步态训练的亚急性卒中患者提供一种有前途的治疗策略。 (C) 2018 Elsevier Ltd. 保留所有权利。
The observation of walking improves gait ability in chronic stroke survivors. It has also been suggested that activation of the mirror neuron system contributes to this effect. However, activation of the mirror neuron system during gait observation has not yet been assessed in sub-acute stroke patients. The objective of this study was to clarify the activation of mirror neuron system during gait observation in subacute stroke patients and healthy persons. In this study, we sequentially enrolled five sub-acute stroke patients who had undergone gait training and nine healthy persons. We used fMRI to detect neuronal activation during gait observation. During the observation period in the stroke group, neural activity in the left inferior parietal lobule, right and left inferior frontal gyrus was significantly higher than during the rest period. In the healthy group, neural activity in the left inferior parietal lobule, left inferior frontal gyrus, left middle frontal gyrus, left superior temporal lobule and right and left middle temporal gyrus was significantly higher than during the rest period. The results indicate that the mirror neuron system was activated during gait observation in sub-acute stroke patients who had undergone gait training and also in healthy persons. Our findings suggest that gait observation treatment may provide a promising therapeutic strategy in sub-acute stroke patients who have experienced gait training. (C) 2018 Elsevier Ltd. All rights reserved.