Decreased Expression of p12DOC-1 Is Associated with More Advanced Tumor Invasion in Human Gastric Cancer Tissues
Decreased Expression of p12DOC-1 Is Associated with More Advanced Tumor Invasion in Human Gastric Cancer Tissues
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DOI：
10.1159/000208521
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发表时间：
2009-01-01
影响因子：
1.6
通讯作者：
Kim, S.
中科院分区：
文献类型：
--
作者：
Choi, M. -G.;Sohn, T. S.;Kim, S.
背景/目的：p12（DOC-1）是一种众所周知的生长抑制因子，但其在胃癌发生中的作用尚不清楚。本研究探讨p12（DOC-1）在胃癌组织中的表达及其与p53表达的相关性，并探讨其临床意义。方法：应用组织芯片法对180例胃癌组织进行免疫组化染色。分析其临床病理特征及预后意义。结果：在180份组织样本中，85份（47.2%）p53表达阳性，140份（77.8%）p12（DOC-1）表达阴性。p12（DOC-1）阴性表达与肿瘤浸润深度及分期有关（p < 0.05）。p（DOC-1）与p53表达无明显相关性。p12（DOC-1）阳性病例的5年生存率（53.7%）高于pp 12（DOC-1）阴性病例（39.3%）;然而，p12（DOC-1）和p53表达状态均无任何统计学意义的预后价值。多因素分析显示，淋巴结转移、远处转移、淋巴管浸润和神经周围浸润是独立的预后因素。结论：pp 12（DOC-1）可能参与胃癌的发生、发展。其在胃癌发生中的确切作用有待进一步研究。版权所有（c）2009 S. Karger AG，巴塞尔
Background/Aims: p12(DOC-1) is a well-known growth suppressor; however, its role in gastric carcinogenesis is still unclear. We investigated the expression of p12(DOC-1) in gastric cancer tissues and its possible correlation with p53 expression, and determined its clinical significance. Methods: Immunohistochemical staining using the tissue array method was performed on 180 human gastric carcinomas. The clinicopathological features and prognostic significance were analyzed. Results: Of the 180 tissue samples, p53 expression was positive in 85 (47.2%) and p12(DOC-1) expression was negative in 140 (77.8%). The negative expression of p12(DOC-1) was significantly associated with a more advanced depth of tumor invasion and stage (p < 0.05). No apparent correlation was found between p(DOC-1) and p53 expressions. The 5-year survival rate of the p12(DOC-1)-positive cases (53.7%) was higher than that of the pp12(DOC-1)-negative cases (39.3%); however, neither p12(DOC-1) nor p53 expression status had any statistically significant prognostic value. Multivariate analysis revealed that lymph node metastasis, distant metastasis, lymphatic invasion and perineural invasion were independent prognostic factors. Conclusions: This is the first report that suggests that pp12(DOC-1) may be involved in the development and progression of gastric cancer. Further studies are required to clarify its exact role in the mechanism of gastric carcinogenesis. Copyright (c) 2009 S. Karger AG, Basel