Developing stratified epithelia: lessons from the epidermis and thymus.
Developing stratified epithelia: lessons from the epidermis and thymus.
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发育分层上皮：表皮和胸腺的教训。
DOI：
10.1002/wdev.146
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Horsley,Valerie
中科院分区：
文献类型：
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作者：
Roberts,Natalie;Horsley,Valerie
复层鳞状上皮细胞存在于许多器官中，包括皮肤表皮和胸腺。发育中的表皮的祖细胞形成多层上皮和附属物，如毛囊，形成重要的屏障，防止水分流失和外来病原体的入侵。相比之下，胸腺上皮形成角质形成细胞的三维网格，这对于自我限制性 T 细胞的阳性和阴性选择至关重要。虽然这些不同的分层上皮组织源自不同的胚胎胚层，但这两种组织都指导免疫，并且控制其发育的上皮分化程序和分子机制非常相似。在这篇综述中，我们的目的是强调胸腺和皮肤表皮及其附属物在发育规范过程中的一些相似之处。WIREs Dev Biol2014, 3:389–402。 doi: 10.1002/wdev.146本文分类为：信号通路 > 细胞命运信号转导成体干细胞、组织更新和再生 > 组织干细胞和生态位
Stratified squamous epithelial cells are found in a number of organs, including the skin epidermis and the thymus. The progenitor cells of the developing epidermis form a multi‐layered epithelium and appendages, like the hair follicle, to generate an essential barrier to protect against water loss and invasion of foreign pathogens. In contrast, the thymic epithelium forms a three‐dimensional mesh of keratinocytes that are essential for positive and negative selection of self‐restricted T cells. While these distinct stratified epithelial tissues derive from distinct embryonic germ layers, both tissues instruct immunity, and the epithelial differentiation programs and molecular mechanisms that control their development are remarkably similar. In this review, we aim to highlight some of the similarities between the thymus and the skin epidermis and its appendages during developmental specification.WIREs Dev Biol2014, 3:389–402. doi: 10.1002/wdev.146This article is categorized under:Signaling Pathways > Cell Fate SignalingAdult Stem Cells, Tissue Renewal, and Regeneration > Tissue Stem Cells and Niches