Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk -: The Framingham study
Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk -: The Framingham study
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DOI：
10.1161/01.atv.20.5.1323
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发表时间：
2000-05-01
影响因子：
8.7
通讯作者：
Schaefer, EJ
中科院分区：
文献类型：
--
作者：
Ordovas, JM;Cupples, LA;Schaefer, EJ
胆固醇酯转移蛋白（CETP）促进脂蛋白颗粒之间甘油三酯和胆固醇酯的交换，这是人体胆固醇逆向转运的关键步骤。CETP基因座的变异已被证明是CETP水平和活性以及高密度脂蛋白（HDL）血浆浓度的决定因素。在来自Fragmentary Offspring研究的1411名男性和1505名女性的人群样本中，研究了常见CETP多态性（内含子1中的TaqIB）与脂蛋白水平和颗粒大小分布、CETP活性和冠心病（CHD）风险的相关性。B2等位基因频率男性为0.444，女性为0.433，与对照组相比差异有显著性（P
Cholesteryl ester transfer protein (CETP) facilitates the exchange of triglycerides and cholesteryl esters between lipoprotein particles, a key step in reverse cholesterol transport in humans. Variations at the CETP locus have been shown to be determinants of the levels and activity of CETP and high density lipoprotein (HDL) plasma concentration. The associations of the common CETP polymorphism, TaqIB in intron 1, with lipoprotein levels and particle size distribution, CETP activity, and coronary heart disease (CHD) risk were examined in a population-based sample of 1411 men and 1505 women from the Framingham Offspring Study. The B2 allele frequency was 0.444 in men and 0.433 in women, and its presence was significantly (P