Maternal Attitudes Toward DNA Collection for Gene-Environment Studies: A Qualitative Research Study
Maternal Attitudes Toward DNA Collection for Gene-Environment Studies: A Qualitative Research Study
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DOI：
10.1002/ajmg.a.33043
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发表时间：
2009-11-01
影响因子：
2
通讯作者：
Honein, Margaret A.
中科院分区：
文献类型：
--
作者：
Jenkins, Mary M.;Reed-Gross, Erika;Honein, Margaret A.
为了评估流行病学研究中对DNA收集的态度，2007年9月，参加过出生缺陷病例对照研究的母亲们组成了焦点小组。在2004年7月至2007年7月期间，每一位被招募的母亲之前都完成了一次访谈，并收到了一个邮寄的工具包，其中包含细胞刷，用于收集她自己、她的婴儿和婴儿的父亲的口腔细胞DNA。共有38名母亲参加了六个焦点小组，包括：(1)病例婴儿的非西班牙裔黑人母亲参与或(2)未参与DNA收集，(3)病例婴儿出生体重过低的任何种族或民族的母亲参与或(4)未参与DNA收集，以及(5)对照组婴儿的非西班牙裔黑人母亲参与或(6)未参与DNA收集。主持人主导的讨论探讨了产妇对提供标本的态度，影响决策的因素，以及收集方法的偏好。生物制剂的参与者报告说，他们提供DNA是出于利他的原因。生物制剂非参与者对政府的介入以及他们的DNA将如何被利用表示担忧。提供（或不提供）有关DNA使用、储存和处置的信息影响决策。生物制剂参与者和非参与者报告说，父亲的怀疑是参与的障碍。所有母亲都被要求根据偏好对DNA采集方法进行排序（细胞刷、唾液、漱口水、新生儿血斑和血液采集）。首选方法方便、无创。更好地了解人们对DNA采集的态度和偏好的采集方法可能会让更多的人参与其中，并有利于未来的研究。2009年Wiley-Liss出版（匕首）
To assess attitudes toward DNA collection in an epidemiological study, focus groups were assembled in September 2007 with mothers who had participated in a case-control study of birth defects. Each recruited mother previously had completed an interview and had received a mailed kit containing cytobrushes to collect buccal cells for DNA from herself, her infant, and her infant's father during the period July 2004 through July 2007. A total of 38 mothers attended six focus groups comprising: (1) non-Hispanic Black mothers of case infants who participated or (2) did not participate in DNA collection, (3) mothers of any race or ethnicity who had case infants of low birth weight who participated or (4) did not participate in DNA collection, and (5) non-Hispanic Black mothers of control infants who participated or (6) did not participate in DNA collection. Moderator-led discussions probed maternal attitudes toward providing specimens, factors that influenced decision making, and collection method preferences. Biologics participants reported that they provided DNA for altruistic reasons. Biologics nonparticipants voiced concerns about government involvement and how their DNA will be used. Information provided (or not provided) on DNA use, storage, and disposal influenced decision making. Biologics participants and nonparticipants reported that paternal skepticism was a barrier to participation. All mothers were asked to rank DNA collection methods in terms of preference (cytobrushes, saliva, mouthwash, newborn blood spots, and blood collection). Preferred methods were convenient and noninvasive. Better understanding attitudes toward DNA collection and preferred collection methods might allow more inclusive participation and benefit future studies. Published 2009 Wiley-Liss, Inc.(dagger)