Gold nanoparticles enable selective light-induced contents release from liposomes
Gold nanoparticles enable selective light-induced contents release from liposomes
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DOI：
10.1016/j.jconrel.2007.06.009
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发表时间：
2007-09-11
影响因子：
10.8
通讯作者：
Urth, Arto
中科院分区：
文献类型：
--
作者：
Paasonen, Lauri;Laaksonen, Timo;Urth, Arto
提出了一种新的原理证明，即光照射可选择性激活脂质体释放内容物。将内容物释放温度调节到略高于体温，将疏水或亲水金纳米颗粒分别掺入脂质双分子层或脂质体核心。在脂质体暴露于紫外光下监测荧光标记物的释放。含金纳米颗粒的脂质体在37℃下保持完整，但紫外光诱导的金纳米颗粒加热触发了内容物的释放。这种光诱导释放是由金纳米颗粒到脂质的热传递和随后的相变介导的。加热高度局限于脂质体中，金纳米颗粒充当能量收集器，使脂质体对光信号敏感。这种选择性是非常有利的，因为它可以潜在地使药物传递机制在生物学上更加兼容。触发的内容释放也可以扩展到需要本地内容释放的其他应用程序。(c) 2007 Elsevier B.V.版权所有
A novel proof of principle demonstration for contents release from liposomes that can be selectively activated by light irradiation is presented. The content release temperature was adjusted to slightly above body temperature, and hydrophobic or hydrophilic gold nanoparticles were incorporated into the lipid bilayer or the core of the liposomes, respectively. The release of a fluorescent marker was monitored upon exposure of the liposomes to UV light. Gold nanoparticle-containing liposomes remained intact at 37 C but contents release was triggered by UV light-induced heating of the gold nanoparticles. This light-induced release is mediated by heat transfer from the gold nanoparticles to the lipids and subsequent phase transition. Heating is highly localized in the liposomes and the gold nanoparticles act as energy collectors that sensitize the liposomes to the light signal. This kind of selectivity is very advantageous as it can potentially make the drug delivery mechanism biologically more compatible. The triggered contents release could also be extended to other applications where local contents release is needed. (c) 2007 Elsevier B.V. All rights reserved.