Continuous attractor network models of grid cell firing based on excitatory-inhibitory interactions.
Continuous attractor network models of grid cell firing based on excitatory-inhibitory interactions.
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DOI：
10.1113/jp270630
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发表时间：
2016-11-15
期刊：
影响因子：
--
通讯作者：
Nolan MF
中科院分区：
文献类型：
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作者：
Shipston-Sharman O;Solanka L;Nolan MF
内侧内嗅皮层中的神经元通过具有网格状组织的空间发射场编码位置。通过对内侧内嗅回路的实验和理论研究，已经解决了识别网格放电机制的挑战。在这里，我们讨论了连续吸引子网络模型，占兴奋性和抑制性细胞之间的突触相互作用的网格发射的证据。这些模型假设网格状的放电模式是从速度输入计算位置的结果，需要额外的空间输入来对抗吸引子状态的漂移。我们专注于连续吸引子网络的属性，通过明确考虑兴奋性和抑制性神经元，它们的连接性和膜电位动力学来揭示。这种细节水平的模型可以解释θ嵌套伽马振荡以及网格发射，预测中间神经元以及兴奋性细胞的空间发射，显示伽马振荡如何独立于空间计算进行调制，揭示神经元噪声的关键作用，并证明网络中只有一部分兴奋性细胞需要具有网格状发射场。根据详细的网络模型预测评估实验数据对于建立介导网格激发的机制将是重要的。
Neurons in the medial entorhinal cortex encode location through spatial firing fields that have a grid‐like organisation. The challenge of identifying mechanisms for grid firing has been addressed through experimental and theoretical investigations of medial entorhinal circuits. Here, we discuss evidence for continuous attractor network models that account for grid firing by synaptic interactions between excitatory and inhibitory cells. These models assume that grid‐like firing patterns are the result of computation of location from velocity inputs, with additional spatial input required to oppose drift in the attractor state. We focus on properties of continuous attractor networks that are revealed by explicitly considering excitatory and inhibitory neurons, their connectivity and their membrane potential dynamics. Models at this level of detail can account for theta‐nested gamma oscillations as well as grid firing, predict spatial firing of interneurons as well as excitatory cells, show how gamma oscillations can be modulated independently from spatial computations, reveal critical roles for neuronal noise, and demonstrate that only a subset of excitatory cells in a network need have grid‐like firing fields. Evaluating experimental data against predictions from detailed network models will be important for establishing the mechanisms mediating grid firing.