Circulating let-7 Levels in Serum Correlate With the Severity of Hepatic Fibrosis in Chronic Hepatitis C.
Circulating let-7 Levels in Serum Correlate With the Severity of Hepatic Fibrosis in Chronic Hepatitis C.
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DOI：
10.1093/ofid/ofy268
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发表时间：
2018-11
影响因子：
4.2
通讯作者：
Tanaka Y
中科院分区：
文献类型：
--
作者：
Matsuura K;Aizawa N;Enomoto H;Nishiguchi S;Toyoda H;Kumada T;Iio E;Ito K;Ogawa S;Isogawa M;Alter HJ;Tanaka Y
评估慢性丙型肝炎（CHC）肝纤维化的进展至关重要，确定纤维化的预测生物标志物将有助于通过抗病毒治疗消除丙型肝炎病毒后实施肝细胞癌的个性化监测。本研究旨在探讨循环let-7a-5p水平与肝纤维化严重程度的关系。 我们通过定量实时聚合酶链反应分析了 84 名接受肝活检的日本 CHC 患者的血清和血清来源的细胞外囊泡 (EV) 中的循环 let-7a-5p 水平，并研究了其水平与组织学肝纤维化阶段、肝脏硬度和几种肝纤维化标志物的关联。肝硬化患者血清和EVs中let-7a-5p的水平显着降低。此外，通过瞬时弹性成像评估，血清let-7a-5p水平与肝纤维化标志物、Mac-2结合蛋白聚糖异构体（M2BPGi）、纤维化-4（FIB-4）指数、天冬氨酸转氨酶与血小板比率指数（APRI）和肝脏硬度显着相关。此外，血清let-7a-5p水平优于M2BPGi、FIB-4和APRI，并且在鉴别肝硬化方面与肝脏硬度相当。 这些结果提供证据表明，血清中循环的let-7a-5p可以作为CHC肝纤维化严重程度的替代标志物。
Evaluating the progression of hepatic fibrosis in chronic hepatitis C (CHC) is critical, and identifying a predictive biomarker for fibrosis will be helpful for implementing personalized surveillance of hepatocellular carcinoma after the elimination of hepatitis C virus by antiviral therapy. This study aimed to investigate the association of circulating let-7a-5p levels with severity of hepatic fibrosis. We analyzed circulating let-7a-5p levels in serum and serum-derived extracellular vesicles (EVs) in 84 Japanese CHC patients who underwent a liver biopsy by quantitative real-time polymerase chain reaction, and investigated the association of its levels with histological hepatic fibrotic stage, liver stiffness, and several hepatic fibrotic markers. The levels of let-7a-5p in serum and EVs were significantly lower in patients with liver cirrhosis. Additionally, the serum let-7a-5p level correlated significantly with hepatic fibrotic markers, Mac-2 binding protein glycan isomer (M2BPGi), fibrosis-4 (FIB-4) index, aspartate aminotransferase-to-platelet ratio index (APRI), and liver stiffness, evaluated by transient elastography. Furthermore, the serum let-7a-5p level was superior to M2BPGi, FIB-4, and APRI and was comparable to liver stiffness in discriminating liver cirrhosis. These results provide evidence that circulating let-7a-5p in serum may serve as a surrogate marker for severity of hepatic fibrosis in CHC.
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