Effect of statins on proteolytic activity in the wall of abdominal aortic aneurysms
Effect of statins on proteolytic activity in the wall of abdominal aortic aneurysms
复制标题
DOI：
10.1002/bjs.5989
复制
发表时间：
2008-03-01
影响因子：
9.6
通讯作者：
Smith, A.
中科院分区：
文献类型：
--
作者：
Abisi, S.;Burnand, K. G.;Smith, A.
背景资料：为探讨他汀类药物对腹主动脉瘤（AAA）瘤壁蛋白酶活性的影响，方法：检测82例AAA修补术患者AAA瘤壁提取液中基质金属蛋白酶（MMPs）9、3、组织蛋白酶B、H、K、L、S的活性及胱抑素C的含量; 21例患者术前接受他汀类药物治疗。所有值均针对提取物中的可溶性蛋白（SP）浓度进行标准化，并报告为中位数（四分位距）或平均值（s.e.m.）。结果：两组的人口统计学特征相似。MMP-9活性降低（43（34-56）对80（62-110）pg/mg SP; P < 0.001），组织蛋白酶H（183（117-366）与321（172-644）nmol 4-甲基香豆素-7-酰胺释放/mg SP; P = 0.016）和组织蛋白酶L（102（51-372）vs. 287（112-816）μ mol 7-氨基-4-三氟甲基香豆素释放/mg SP; P = 0.020）在他汀类药物治疗的前列腺癌中发现，与来自未服用他汀类药物患者的AAA相比。他汀类药物治疗组MMP-3活性较低，但未达到统计学显著性（P = 0.053）。他汀类药物治疗的动脉瘤患者胱抑素C水平高于对照组（41.3（3.1）ng/mg SP vs 28.9（2.1）ng/mg SP; P = 0.003）。结论：他汀类药物降低了与动脉瘤疾病有关的蛋白酶活性。
Background: The aim of this study was to examine the effect of statin treatment on the activity of proteases in the wall of abdominal aortic aneurysms (AAAs).Methods: The activities of matrix metalloproteinases (MMPs) 9 and 3, cathepsins B, H, K, L and S, and the cystatin C level were measured in extracts of AAA wall taken from 82 patients undergoing AAA repair; 21 patients were receiving statin treatment before surgery. All values were standardized against soluble protein (SP) concentration in the extract, and reported as median (interquartile range) or mean(s.e.m.).Results: The two groups had similar demographics. Reduced activity of MMP-9 (43 (34-56) versus 80 (62-110) pg per mg SP; P < 0.001), cathepsin H (183 (117-366) versus 321 (172-644) nmol 4-methylcoumarin-7-amide released per mg SP; P = 0.016) and cathepsin L (102 (51-372) versus 287 (112-816) mu mol 7-amino-4-trifluoromethylcoumarin released per mg SP; P = 0.020) was found in the statin-treated aortas compared with AAAs from patients not taking a statin. The statin-treated group had lower MMP-3 activity, but this did not reach statistical significance (P = 0.053). Cystatin C levels were higher in statin-treated aortas than in controls (41.3(3.1) versus 28.9(2.1) ng per mg SP; P = 0.003).Conclusion: Statins decreased the activity of proteases that have been implicated in aneurysm disease.