Lymphocyte transformation induced by autologous cells. VIII. Impaired autologous mixed lymphocyte reactivity in patients with acute infectious mononucleosis.
Lymphocyte transformation induced by autologous cells. VIII. Impaired autologous mixed lymphocyte reactivity in patients with acute infectious mononucleosis.
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DOI：
10.1084/jem.150.6.1448
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发表时间：
1979-12-01
期刊：
影响因子：
--
通讯作者：
Weksler ME
中科院分区：
文献类型：
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作者：
Moody CE;Casazza BA;Christenson WN;Weksler ME
急性传染性单核细胞增多症患者的自体混合淋巴细胞反应（MLR）严重受损。恢复期反应性恢复。这些患者的同种异体MLR未受损。来自传染性单核细胞增多症患者的B细胞不会刺激自体t细胞增殖，这一观察似乎解释了感染中受损的自体MLR的细胞基础。考虑了b细胞缺陷的两种解释：(a)血清因子对b细胞功能的影响；(b) eb病毒感染的影响。
The autologous mixed lymphocyte reaction (MLR) is severely impaired in patients with acute infectious mononucleosis. Reactivity returned during the course of convalescence. The allogeneic MLR was not impaired in these patients. B cells from patients with infectious mononucleosis do not stimulate autologous T-cell proliferation, and this observation appears to explain the cellular basis of the impaired autologous MLR in infection. Two explanations for the B-cell defect were considered: (a) the influence of serum factors on B-cell function and (b) the effect of Epstein-Barr virus infection.