Chronic quercetin ingestion and exercise-induced oxidative damage and inflammation
Chronic quercetin ingestion and exercise-induced oxidative damage and inflammation
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DOI：
10.1139/h07-177
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发表时间：
2008-04-01
影响因子：
3.4
通讯作者：
Dibarnardi, Adrianna
中科院分区：
文献类型：
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作者：
McAnulty, Steven R.;McAnulty, Lisa S.;Dibarnardi, Adrianna
槲皮素是一种黄酮类化合物，已被证明是一种有效的体外抗氧化剂。本研究的目的是评估摄入槲皮素是否会增加血浆抗氧化措施，并减弱运动诱导的氧化损伤的增加。40名运动员被招募并随机接受槲皮素或安慰剂治疗。受试者每天服用1000 mg槲皮素或安慰剂，持续6周，然后以57%的最大工作量进行3 h的3 d自行车运动。每天运动前和运动后立即采集血液，并分析F2-异前列腺素、亚硝酸盐、血浆铁还原能力、trolox等效抗氧化能力和C反应蛋白。统计分析涉及2（处理）× 6（次）重复测量方差分析，以检验主效应。F2-异前列腺素、亚硝酸盐、血浆铁还原能力、trolox等效抗氧化能力和C-反应蛋白作为运动的结果显著升高，但没有发现组效应。这项研究表明，这种作用在体内是不存在的，长期摄入槲皮素不会对运动产生保护作用，引起氧化应激和炎症。
Quercetin is a flavonoid compound that has been demonstrated to be a potent antioxidant in vitro. The objective of this study was to evaluate if quercetin ingestion would increase plasma antioxidant measures and attenuate increases in exercise-induced oxidative damage. Forty athletes were recruited and randomized to quercetin or placebo. Subjects consumed 1000 mg quercetin or placebo each day for 6 weeks before and during 3 d of cycling at 57% work maximum for 3 h. Blood was collected before and immediately after exercise each day, and analyzed for F2-isoprostanes, nitrite, ferric-reducing ability of plasma, trolox equivalent antioxidant capacity, and C-reactive protein. Statistical analyses involved a 2 (treatment) x 6 (times) repeated measures analysis of variance to test main effects. F2-isoprostanes, nitrite, ferric-reducing ability of plasma, trolox equivalent antioxidant capacity, and C-reactive protein were significantly elevated as a result of exercise, but no group effects were found. Despite previous data demonstrating potent antioxidant actions of quercetin in vitro, this study indicates that this effect is absent in vivo and that chronic quercetin ingestion does not exert protection from exercise-induced oxidative stress and inflammation.