Intranasal Oxytocin Improves Emotion Recognition for Youth with Autism Spectrum Disorders
Intranasal Oxytocin Improves Emotion Recognition for Youth with Autism Spectrum Disorders
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DOI：
10.1016/j.biopsych.2009.09.020
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发表时间：
2010-04-01
影响因子：
10.6
通讯作者：
Hickie, Ian B.
中科院分区：
文献类型：
--
作者：
Guastella, Adam J.;Einfeld, Stewart L.;Hickie, Ian B.
背景：自闭症谱系障碍的一个诊断标志是社会沟通和互动的质量障碍。识别他人情绪的能力不足被认为是造成这种情况的原因。目前对这些问题还没有有效的治疗方法。方法：在双盲、随机、安慰剂对照、交叉设计中，我们给16名年龄在12至19岁之间被诊断为自闭症或阿斯伯格障碍的男性青年服用催产素鼻喷雾剂（18或24 IU）或安慰剂。然后，参与者完成了“通过眼睛读心”任务，这是一项广泛使用且可靠的情绪识别测试。结果：与安慰剂相比，催产素改善了在“通过眼睛读心”任务中的表现。当分析仅限于接受较低剂量的12至15岁的年轻参与者时，也显示出这种效果。结论：本研究首次提供了催产素鼻腔喷雾剂改善自闭症谱系障碍青少年情绪识别的证据。研究结果表明，早期干预和进一步评估后叶催产素鼻腔喷雾剂作为改善自闭症谱系障碍青少年社会沟通和互动的治疗方法的潜力。
Background: A diagnostic hallmark of autism spectrum disorders is a qualitative impairment in social communication and interaction. Deficits in the ability to recognize the emotions of others are believed to contribute to this. There is currently no effective treatment for these problems.Methods: In a double-blind, randomized, placebo-controlled, crossover design, we administered oxytocin nasal spray (18 or 24 IU) or a placebo to 16 male youth aged 12 to 19 who were diagnosed with Autistic or Asperger's Disorder. Participants then completed the Reading the Mind in the Eyes Task, a widely used and reliable test of emotion recognition.Results: In comparison with placebo, oxytocin administration improved performance on the Reading the Mind in the Eyes Task. This effect was also shown when analysis was restricted to the younger participants aged 12 to 15 who received the lower dose.Conclusions: This study provides the first evidence that oxytocin nasal spray improves emotion recognition in young people diagnosed with autism spectrum disorders. Findings suggest the potential of earlier intervention and further evaluation of oxytocin nasal spray as a treatment to improve social communication and interaction in young people with autism spectrum disorders.