Role of dyslipidemia in accelerating inflammation, autoimmunity, and atherosclerosis in systemic lupus erythematosus and other autoimmune diseases.
Role of dyslipidemia in accelerating inflammation, autoimmunity, and atherosclerosis in systemic lupus erythematosus and other autoimmune diseases.
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发表时间：
2020
影响因子：
1.4
通讯作者：
Yaodong Wang;Haitao Yu;Jinchun He
中科院分区：
文献类型：
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作者：
Yaodong Wang;Haitao Yu;Jinchun He
血脂异常是指脂质代谢异常。血脂异常通常表现为低密度脂蛋白胆固醇（LDL-c）、总胆固醇（TC）、甘油三酯（TG）、载脂蛋白B（Apo B）的血浆水平升高和高密度脂蛋白胆固醇（HDL-c）水平降低。血脂异常常发生在自身免疫性疾病（AD）中，如系统性红斑狼疮（SLE）、类风湿性关节炎（RA）、1型糖尿病（T1 DM）、银屑病和炎症性肠病（IBD）以及许多其他疾病。脂质代谢的不平衡除了促进动脉粥样硬化的形成之外，还有助于加速炎症反应。虽然关于脂代谢异常与AD的关系已有许多研究和报道，但血脂异常是否在AD的发生发展中具有独特的促进作用尚不明确。本文主要以SLE为例，从流行病学、分子水平和细胞水平探讨血脂异常加速炎症反应、自身免疫和动脉粥样硬化的机制。
Dyslipidemia refers to the abnormality of lipid metabolism. The aberrant lipid profiles are usually characterized by elevated plasma levels of low-density lipoprotein cholesterol (LDL-c), total cholesterol (TC), triglycerides (TGs), apoprotein B (ApoB), and decreased level of high-density lipoprotein cholesterol (HDL-c). Dyslipidemia occurs frequently in autoimmune diseases (ADs), such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), type-1 diabetes mellitus (T1DM), psoriasis, and inflammatory bowel disease (IBD), and many other diseases. An imbalance in lipid metabolism contributes to accelerated inflammatory responses in addition to promoting the formation of atherosclerosis. Although there have been many studies and reports on the relationship between abnormal lipid metabolism and ADs, it remains uncertain as to whether dyslipidemia has a unique role in promoting the occurrence and development of ADs. Here, we discuss the mechanisms of how dyslipidemia accelerates inflammatory response, autoimmunity, and atherosclerosis at epidemiological, molecular, and cellular levels, and the discussion is mainly conducted with SLE as an example.