Prediction error and trace dominance determine the fate of fear memories after post-training manipulations.
Prediction error and trace dominance determine the fate of fear memories after post-training manipulations.
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DOI：
10.1101/lm.038513.115
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Urcelay GP
中科院分区：
文献类型：
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作者：
Alfei JM;Ferrer Monti RI;Molina VA;Bueno AM;Urcelay GP
当CS暴露激活联想记忆，然后是遗忘时，观察到不同的助记结果。这些结果包括仅仅是恢复、不稳定-再巩固、过渡期(对遗忘不敏感)和灭绝学习。然而，在强化或非强化再激活过程中，初始学习条件与这些结果之间的相互作用知之甚少。在这里，我们系统地将时间特定记忆与不同的再激活参数相结合，以观察这四种结果是否由训练过程中建立的条件决定。首先，我们验证了两种训练方案，它们对美国人的抵达具有不同的时间预期。然后，使用咪达唑仑(MDZ)作为健忘剂，在与原始训练相同或不同的参数下，对两种学习条件下的恐惧记忆进行再训练。如果出现关于美国抵达的时间预测错误，当重新激活得到加强时，就会发生不稳定(即，容易受到MDZ的影响)。在随后的实验中，两个处理都被不同长度的非强化情境暴露系统地重新激活，这使得可以探索训练和重新激活长度之间的交互作用。这些结果表明，时间预测误差和轨迹优势决定了重新激活产生不同结果的程度。
Different mnemonic outcomes have been observed when associative memories are reactivated by CS exposure and followed by amnestics. These outcomes include mere retrieval, destabilization–reconsolidation, a transitional period (which is insensitive to amnestics), and extinction learning. However, little is known about the interaction between initial learning conditions and these outcomes during a reinforced or nonreinforced reactivation. Here we systematically combined temporally specific memories with different reactivation parameters to observe whether these four outcomes are determined by the conditions established during training. First, we validated two training regimens with different temporal expectations about US arrival. Then, using Midazolam (MDZ) as an amnestic agent, fear memories in both learning conditions were submitted to retraining either under identical or different parameters to the original training. Destabilization (i.e., susceptibly to MDZ) occurred when reactivation was reinforced, provided the occurrence of a temporal prediction error about US arrival. In subsequent experiments, both treatments were systematically reactivated by nonreinforced context exposure of different lengths, which allowed to explore the interaction between training and reactivation lengths. These results suggest that temporal prediction error and trace dominance determine the extent to which reactivation produces the different outcomes.