Risk factors for West Nile virus infection and meningoencephalitis, Romania, 1996
Risk factors for West Nile virus infection and meningoencephalitis, Romania, 1996
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DOI：
10.1086/314566
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发表时间：
1999-01-01
影响因子：
6.4
通讯作者：
Tsai, TF
中科院分区：
文献类型：
--
作者：
Han, LL;Popovici, F;Tsai, TF
1996年，罗马尼亚东南部发生了393例实验室确诊的西尼罗河脑膜脑炎流行病，广泛存在亚临床人类感染。进行了两项病例对照研究，以确定获得性感染和感染后发展为临床脑膜脑炎的危险因素。家中的蚊子与感染有关（38名无症状血清反应阳性者中有37名[97%]报告，50名血清反应阴性对照者中有36名[72%]报告，P < .01），在公寓居民中，地下室被淹是一个危险因素（24名血清阳性患者中有15名[63%]报告，37名血清阴性对照中有11名[30%]报告，P = 0.01）。脑膜脑炎与高血压或其他基础疾病无关，但与户外活动时间增加有关（脑膜脑炎患者和无症状血清学阳性者每天户外活动时间分别为8.0和3.5小时[中位数]，P
In 1996, an epidemic of 393 cases of laboratory-confirmed West Nile meningoencephalitis occurred in southeast Romania, with widespread subclinical human infection, Two case-control studies were performed to identify risk factors for acquiring infection and for developing clinical meningoencephalitis after infection. Mosquitoes in the home were associated with infection (reported by 37 [97%] of 38 asymptomatically seropositive persons compared with 36 [72%] of 50 seronegative controls, P < .01) and, among apartment dwellers, flooded basements were a risk factor (reported by 15 [63%] of 24 seropositive persons vs. 11 [30%] of 37 seronegative controls, P = .01). Meningoencephalitis was not associated with hypertension or other underlying medical conditions but was associated with spending more time outdoors (meningoencephalitis patients and asymptomatically seropositive persons spent 8.0 and 3.5 h [medians] outdoors daily, respectively, P