THE SENSITIVITIES TO RADIATIONS AND RADIOMIMETIC CHEMICALS OF CELLS FROM PATIENTS WITH ATAXIA TELANGIECTASIA
THE SENSITIVITIES TO RADIATIONS AND RADIOMIMETIC CHEMICALS OF CELLS FROM PATIENTS WITH ATAXIA TELANGIECTASIA
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DOI：
10.1007/bf01897042
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发表时间：
1983-01-01
期刊：
影响因子：
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通讯作者：
MIMAKI, T
中科院分区：
文献类型：
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作者：
IKENAGA, M;MIDORIKAWA, M;MIMAKI, T
通过细胞集落形成能力测定了物理和化学试剂对来自患有共济失调毛细血管扩张症（AT）的日本患者的成纤维细胞株的致死作用，并与英国AT细胞株进行了比较。与正常成纤维细胞相比，AT株对X射线和抗肿瘤剂博来霉素的敏感性显着增加。2株AT对甲磺酸甲酯的敏感性略高于正常细胞。与正常细胞相比，英国AT株（AT 4 BI）对4-硝基喹啉1-氧化物和丝裂霉素C表现出明显的敏感性，而日本AT株（AT 1 OS）对4-硝基喹啉1-氧化物表现出正常的反应，而对丝裂霉素C的敏感性降低。在这些实验条件下，AT 1 OS细胞对N-甲基-N“-硝基-N-亚硝基胍的敏感性也是正常的。
The lethal action of physical and chemical agents on a fibroblast strain derived from a Japanese patient with ataxia telangiectasia (AT) was measured by the cellular colony forming ability, in comparison with a British AT cell strain. Both of the AT strains showed a significantly increased sensitivity to X-rays and an antitumor agent bleomycin, as compared with normal fibroblasts. The 2 AT strains were slightly more sensitive to methyl methanesulfonate than normal cells. The British AT strain (AT4BI) exhibited a marked sensitivity to 4-nitroquinoline 1-oxide and to mitomycin C compared with normal cells, whereas the Japanese AT strain (AT1OS) showed normal response to 4-nitroquinoline 1-oxide and a reduced sensitivity to mitomycin C. Sensitivity of AT1OS cells to N-methyl-N''-nitro-N-nitrosoguanidine was also normal under these experimental conditions.