Combination therapy with ciprofloxacin plus azlocillin against Pseudomonas aeruginosa: effect of simultaneous versus staggered administration in an in vitro model of infection.
Combination therapy with ciprofloxacin plus azlocillin against Pseudomonas aeruginosa: effect of simultaneous versus staggered administration in an in vitro model of infection.
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DOI：
10.1093/infdis/164.3.499
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发表时间：
1991-09
期刊：
影响因子：
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通讯作者：
M. Dudley;J. Blaser;D. Gilbert;K. Mayer;S. Zinner
中科院分区：
文献类型：
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作者：
M. Dudley;J. Blaser;D. Gilbert;K. Mayer;S. Zinner
在二室体外感染动力学模型中，研究了剂量调度对模拟人体剂量的环丙沙星（200 mg静脉注射[iv]，每12 h一次）和阿洛西林（4 g静脉注射，每12 h一次）单独或联合抗铜绿假单胞菌的药效学的影响。使用同时或交错（每种药物的首次给药间隔6小时）给药方案比较了两种药物联合给药的研究。所有联合给药方案均防止了细菌再生长和耐药性;然而，同时给药方案始终为所有菌株提供了最大程度的杀灭，特别是在最初对环丙沙星耐药的菌株中。在模型的类似“血清”隔室中杀菌活性的峰值和持续时间的增加证实了组合的这些增强的作用。这些数据显示了抗假单胞菌β-内酰胺与环丙沙星同时给药对抗铜绿假单胞菌的潜在有用性。
The effect of dose scheduling on the pharmacodynamics of simulated human doses of ciprofloxacin (200 mg intravenously [iv] every 12 h) and azlocillin (4 g iv every 12 h) alone or in combination against Pseudomonas aeruginosa was studied in a two-compartment in vitro kinetic model of infection. Studies with the two drugs in combination were compared using simultaneous or staggered (first doses of each drug were administered 6 h apart) dosing schedules. Bacterial regrowth and resistance were prevented by all combination dosing schedules; however, the simultaneous regimen consistently provided the greatest extent of killing for all strains, particularly in those initially resistant to ciprofloxacin. These enhanced effects of the combination were corroborated by an increase in the peak and duration of bactericidal activity in the analogous "serum" compartment of the model. These data show the potential usefulness of simultaneous dosing of an antipseudomonal beta-lactam with ciprofloxacin against P. aeruginosa.