Dentithecamides A-H, Diacylated Zoanthoxanthin Derivatives with PAX3-FOXO1 Inhibitory Activity from the Hydroid Dentitheca habereri.
Dentithecamides A-H, Diacylated Zoanthoxanthin Derivatives with PAX3-FOXO1 Inhibitory Activity from the Hydroid Dentitheca habereri.
复制标题
Dentithecamides A-H，来自水螅 Dentitheca habereri 的具有 PAX3-FOXO1 抑制活性的二酰化 Zoanthoxanthin 衍生物。
DOI：
10.1021/acs.jnatprod.2c00246
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发表时间：
2022
影响因子：
5.1
通讯作者：
Gustafson,KirkR
中科院分区：
文献类型：
--
作者：
Jiang,Wei;Tian,Xiangrong;Wang,Dongdong;Bokesch,HeidiR;Thomas,CherylL;Woldemichael,GirmaM;Gryder,BerkleyE;Wei,JunS;Song,YoungK;Chou,Hsien-Chao;Khan,Javed;O'Keefe,BarryR;Gustafson,KirkR
对海洋水合牙藻的化学研究发现了8种新的二酰基化的动物花黄素生物碱，命名为牙酰胺A-H(1-8)，以及3种先前报道的类似物，动物酰胺B-D（9-11）。化合物1 - 11的结构通过IR、hresms、NMR等光谱分析及文献资料对比得到。化合物1 - 11是首次报道的从水合物中分离出来的虫黄质生物碱。牙酰胺A(1)和B(2)以及zoamides B - d（9-11）都有一个构象移动的环七烯核心，它们抑制PAX3-FOXO1调节的转录活性，从而为潜在开发更有效的PAX3-FOXO1抑制剂提供了结构框架。
Chemical investigation of the marine hydroidDentitheca habereriled to the identification of eight new diacylated zoanthoxanthin alkaloids, named dentithecamides A–H (1–8), along with three previously reported analogues, zoamides B–D (9–11). The structures of compounds1–11were elucidated by spectroscopic and spectrometric analyses, including IR, HRESIMS, and NMR experiments, and by comparison with literature data. Compounds1–11are the first zoanthoxanthin alkaloids to be reported from a hydroid. Dentithecamides A (1) and B (2) along with zoamides B–D (9–11), which all share a conformationally mobile cycloheptadiene core, inhibited PAX3-FOXO1 regulated transcriptional activity and thus provided a structural framework for the potential development of more potent PAX3-FOXO1 inhibitors.
影响因子：
3.6
作者：
Williamson, R. Thomas;Buevich, Alexei V.;Parella, Teodor
通讯作者：
Parella, Teodor
Paragracine 的化学成分，一种来自 Parazoanthus gracilis (Lwowsky) 的生物活性海洋碱。
影响因子：
1.7
作者：
Y. Komoda;M. Shimizu;S. Kaneko;M. Yamamoto;M. Ishikawa
通讯作者：
M. Ishikawa