Aromatase inhibitors decrease radiation-induced lung fibrosis: Results of an experimental study
Aromatase inhibitors decrease radiation-induced lung fibrosis: Results of an experimental study
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DOI：
10.1016/j.breast.2016.04.003
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发表时间：
2016-08-01
期刊：
影响因子：
3.9
通讯作者：
Bese, N. S.
中科院分区：
文献类型：
--
作者：
Altinok, A. Y.;Yildirim, S.;Bese, N. S.
目的：在实验和临床试验中，他莫昔芬（TAM）已被证明可增加放射性肺纤维化（RILF）。此外，芳香酶抑制剂（AI）已被证明是上级TAM的辅助设置和临床前数据表明，来曲唑（LET）敏感的乳腺癌细胞电离辐射在其他研究。材料与方法：60只雌性Wistar大鼠随机分为6组：对照组（A组）、单纯RT组（B组）、RT + TAM组（C组）、RT +阿那曲唑组（D组）、RT + LET组（E组）、RT +阿司美坦组（EXE组）。RT包括30戈伊，分10次照射双肺，前野深度为2 cm。根据大鼠的平均体重计算60 kg成人剂量/天的TAM、ANA、LET和EXE的等效剂量，并通过饲管经口给药。用肺组织切片的图像分析定量具有纤维化的肺的百分比。计算每组的平均评分值。结果：A、B、C、D、E和F组的纤维化平均值分别为1.7、5.9、6.7、2.5、2和2.2（p = 0.000）。TAM增加RT诱导的肺纤维化，但无统计学意义。用RT + AI治疗的组显示出比用单独的RT或RT + TAM治疗的组显著更少的肺纤维化（p = 0.000）。RT + AI组显示出几乎相似的RT诱导的肺纤维化比control group.Conclusions：在这项研究中，我们发现，AI减少RT诱导的肺纤维化的对照组的水平表明保护作用。(C)2016爱思唯尔有限公司版权所有
Purpose: In experimental and clinical trials, tamoxifen (TAM) has been shown to increase radiation-induced lung fibrosis (RILF). Furthermore, aromatase inhibitors (AI) have been shown to be superior to TAM in the adjuvant setting and preclinical data suggest that letrozole (LET) sensitizes breast cancer cells to ionizing radiation in other studies. In this experimental study, we evaluated whether AI have any impact on the development of RILF in rats.Materials and methods: 60 female wistar-albino rats were divided into 6 groups: Control (group A), RT alone (group B), RT + TAM (group C), RT + anastrozole (ANA group D), RT + LET (group E), and RT + exemestane (EXE, group F). RT consisted of 30 Gy in 10 fractions to both lungs with an anterior field at 2 cm depth. Equivalent doses for 60 kg adult dose per day of TAM, ANA, LET, and EXE were calculated according to the mean weight of rats and orally administrated with a feeding tube. Percentage of lung with fibrosis was quantified with image analysis of histological sections of the lung. The mean score values were calculated for each group. the significance of the differences among groups were calculated using one way ANOVA test and Tukey HSD post-hoc test.Results: Mean values of fibrosis were 1.7, 5.9, 6.7, 2.5, 2 and 2.2 for groups A, B, C, D, E, and F, respectively (p = 0.000). TAM increased RT-induced lung fibrosis but without statistical significance. Groups treated with RT + AI showed significantly less lung fibrosis than groups treated with RT alone or RT + TAM (p = 0.000). RT + AI groups showed nearly similar RT-induced lung fibrosis than control group.Conclusions: In this study, we found that AI decreased RT-induced lung fibrosis to the control group level suggesting protective effect. (C) 2016 Elsevier Ltd. All rights reserved.