Cytokine stimulation of epithelial cancer cells: the similar and divergent functions of IL-4 and IL-13.
Cytokine stimulation of epithelial cancer cells: the similar and divergent functions of IL-4 and IL-13.
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DOI：
10.1158/0008-5472.can-12-3544
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发表时间：
2012-12-15
期刊：
影响因子：
11.2
通讯作者：
Fingleton B
中科院分区：
文献类型：
--
作者：
Hallett MA;Venmar KT;Fingleton B
Th 2细胞因子白细胞介素-4和-13（IL 4; IL 13）是公认的淋巴细胞增殖和活化的调节剂。在肿瘤生物学中，它们在调节各种骨髓来源的群体中也得到了充分的研究。然而，已经清楚的是，这两种细胞因子可以对表达适当受体的上皮肿瘤细胞具有直接作用。肿瘤增殖、存活和转移能力的变化都归因于IL 4和/或IL 13的作用。在这里，我们评估的证据，以支持这些细胞因子的直接肿瘤促进作用。我们还确定了在进行基于IL 4或IL 13通路的中和的治疗方法之前应该解决的问题。
The Th2 cytokines interleukins-4 and -13 (IL4; IL13) are acknowledged regulators of lymphocyte proliferation and activation. They have also been well-studied in the regulation of various myeloid-derived populations in tumor biology. It has become clear however, that both that cytokines can have direct effects on epithelial tumor cells expressing appropriate receptors. Changes in tumor proliferation, survival and metastatic capability have all been ascribed to IL4 and/or IL13 action. Here, we evaluate the evidence to support direct tumor-promoting roles of these cytokines. We also identify the questions that should be addressed before proceeding with therapeutic approaches based on neutralization of IL4 or IL13 pathways.