A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation
A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation
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DOI：
10.1038/s41467-018-06843-5
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发表时间：
2018-11-16
影响因子：
16.6
通讯作者：
Schiffer, Joshua T.
中科院分区：
文献类型：
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作者：
Reeves, Daniel B.;Duke, Elizabeth R.;Schiffer, Joshua T.
抗逆转录病毒疗法（ART）抑制艾滋病毒感染者的病毒复制。然而，受感染的细胞在ART中持续数十年，如果ART停止，病毒血症就会复发。持续性归因于ART避难所中的病毒复制和长寿命和/或增殖的潜伏感染细胞。使用生态学方法和现有的数据，我们推断，>99%的感染细胞是克隆群体的成员后，一年的ART。我们调和我们的结果与观察从ART的第一个月，从数学上证明了如何历史的HIV复制的化石记录允许观察到的病毒进化，即使大多数新的感染细胞产生的增殖。总之，我们的结果意味着细胞增殖在ART期间产生了大多数感染细胞。因此，减少增殖可以减少HIV库的大小，并有助于实现功能性治愈。
Antiretroviral therapy (ART) suppresses viral replication in people living with HIV. Yet, infected cells persist for decades on ART and viremia returns if ART is stopped. Persistence has been attributed to viral replication in an ART sanctuary and long-lived and/or proliferating latently infected cells. Using ecological methods and existing data, we infer that >99% of infected cells are members of clonal populations after one year of ART. We reconcile our results with observations from the first months of ART, demonstrating mathematically how a fossil record of historic HIV replication permits observed viral evolution even while most new infected cells arise from proliferation. Together, our results imply cellular proliferation generates a majority of infected cells during ART. Therefore, reducing proliferation could decrease the size of the HIV reservoir and help achieve a functional cure.