γδ T cells: Major advances in basic and clinical research in tumor immunotherapy.
γδ T cells: Major advances in basic and clinical research in tumor immunotherapy.
复制标题
γδ T细胞：肿瘤免疫治疗基础和临床研究的重大进展。
DOI：
10.1097/cm9.0000000000002781
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发表时间：
2024-01-05
影响因子：
6.1
通讯作者：
中科院分区：
文献类型：
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作者：
γδT细胞是一种先天免疫T细胞。它们没有引起足够的关注，因为它们只占所有免疫细胞的一小部分，而且与这些细胞相关的许多基本因素尚不清楚。然而，近年来，随着肿瘤免疫治疗的快速发展，γδT细胞因其在不受主要组织相容性复合体限制的情况下对大多数肿瘤细胞发挥细胞毒作用而受到越来越多的关注。越来越多的基础研究集中在γδT细胞的发育、抗原识别、激活和抗肿瘤免疫反应方面。此外，基于γδT细胞的免疫治疗策略正在开发中，研究此类策略的临床试验数量正在增加。本文主要对γδT细胞在肿瘤免疫治疗中的基础研究和临床应用进展进行综述，为今后进一步发展γδT细胞免疫治疗策略提供理论依据。
γδ T cells are a kind of innate immune T cell. They have not attracted sufficient attention because they account for only a small proportion of all immune cells, and many basic factors related to these cells remain unclear. However, in recent years, with the rapid development of tumor immunotherapy, γδ T cells have attracted increasing attention because of their ability to exert cytotoxic effects on most tumor cells without major histocompatibility complex (MHC) restriction. An increasing number of basic studies have focused on the development, antigen recognition, activation, and antitumor immune response of γδ T cells. Additionally, γδ T cell-based immunotherapeutic strategies are being developed, and the number of clinical trials investigating such strategies is increasing. This review mainly summarizes the progress of basic research and the clinical application of γδ T cells in tumor immunotherapy to provide a theoretical basis for further the development of γδ T cell-based strategies in the future.
影响因子：
5.8
作者：
Fowler, Daniel W.;Copier, John;Wilson, Natalie;Dalgleish, Angus G.;Bodman-Smith, Mark D.
通讯作者：
Bodman-Smith, Mark D.
影响因子：
5.2
作者：
通讯作者：
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影响因子：
12.4
作者：
Liu Y;Lui KS;Ye Z;Fung TY;Chen L;Sit PY;Leung CY;Mak NK;Wong KL;Lung HL;Tanaka Y;Cheung AKL
通讯作者：
Cheung AKL