Acute effects of smoking on blood pressure and cerebral blood flow.
Acute effects of smoking on blood pressure and cerebral blood flow.
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吸烟对血压和脑血流量的急性影响。
DOI：
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发表时间：
1989
影响因子：
2.7
通讯作者：
S. Patel
中科院分区：
文献类型：
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作者：
Cruickshank Jm;G. Neil;Dorrance De;Y. Hayes;S. Patel
慢性吸烟，特别是高血压患者，与脑梗死和蛛网膜下腔出血的频率增加有关;慢性吸烟者的脑血流量（CBF）也减少。吸烟对CBF的急性影响尚不清楚。本研究在6名志愿者中调查了吸烟（和吸入）3支香烟的即时影响，每支香烟间隔2小时，对心率、血压（BP）和通过氙气吸入评估的CBF以及通过经颅多普勒超声评估的大脑中动脉流速的影响。吸烟导致心率、血压和大脑中动脉血流速度显著增加，CBF显著下降（半球血流的个体福尔斯下降可高达40%）。这些血液动力学效应可能是由尼古丁诱导的儿茶酚胺释放变化引起的。本文还讨论了高危人群急性吸烟引起的血压和脑血流变化的可能临床意义。
Chronic smoking, particularly in hypertensives, is associated with an increased frequency of cerebral infarction and subarachnoid haemorrhage; cerebral blood flow (CBF) is also decreased in chronic smokers. The acute effects of smoking upon CBF are less clear. The present study in six volunteers investigated the immediate effects of smoking (and inhaling) three cigarettes, each separated by a 2 hr gap, upon heart rate, blood pressure (BP) and CBF assessed by xenon inhalation and flow velocities in the middle cerebral artery by transcranial Doppler ultrasound. Smoking caused significant increases in heart rate, BP and middle cerebral artery flow velocities, and a significant fall in CBF (individual falls in hemispherical flow could be as great as 40%). These haemodynamic effects are probably caused by nicotine-induced changes in catecholamine release. The possible clinical significance of the BP and CBF changes induced by acute smoking in high-risk groups is discussed.