HEPATOCELLULAR-CARCINOMA AND SQUAMOUS-CELL CARCINOMA IN A PATIENT WITH FANCONIS ANEMIA
HEPATOCELLULAR-CARCINOMA AND SQUAMOUS-CELL CARCINOMA IN A PATIENT WITH FANCONIS ANEMIA
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DOI：
10.1007/bf01714963
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发表时间：
1991-07-01
影响因子：
3.5
通讯作者：
GRAU, E
中科院分区：
文献类型：
--
作者：
LINARES, M;PASTOR, E;GRAU, E
急性白血病、肝细胞癌和鳞状细胞癌在范可尼贫血患者中已有报道。 我们报告一位31岁的女性，她同时罹患食道鳞状细胞癌及肝细胞癌。 1981年，在她接受羟甲烯龙治疗10年后，出现了黄疸和肝肿瘤。 肝活检显示肝细胞有紫癜。 停止雄激素治疗，黄疸消退。 然而，观察到肝肿瘤无变化。 患者死于播散性鳞状细胞癌，但尸检中未检测到肝细胞癌转移灶。 范可尼贫血和鳞状细胞癌的关联进行了审查，并讨论了雄激素相关的肝肿瘤的恶性潜力。
Acute leukemia, hepatocellular carcinoma, and squamous cell carcinoma have been reported in patients with Fanconi's anemia. We report on a 31-year-old woman whod eveloped squamous cell carcinoma of the esophagus and hepatocellular carcinoma. Jaundice and hepatic tumor developed in 1981, after she had received oxymetholone for 10 years. Liver biopsy revealed peliosis hepatis. Androgenic therapy was stopped and the jaundice resolved. However, the hepatic tumor was observed to be unchanged. The patient died of disseminated squamous cell carcinoma, but no metastatic lesions from hepatocellular carcinoma were detected in the autopsy. The association of Fanconi's anemia and squamous cell carcinoma is reviewed, and the malignant potential of androgen-related hepatic tumors is discussed.