Plasma dipeptidyl peptidase 4 activity correlates with body mass index and the plasma adiponectin concentration in healthy young people
Plasma dipeptidyl peptidase 4 activity correlates with body mass index and the plasma adiponectin concentration in healthy young people
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DOI：
10.1507/endocrj.ej12-0158
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发表时间：
2012-10-20
影响因子：
2
通讯作者：
Sato, Youichi
中科院分区：
文献类型：
--
作者：
Kirino, Yasushi;Sei, Masako;Sato, Youichi
我们之前通过动物模型发现血浆二肽基肽酶4 （DPP4）活性与肥胖、2型糖尿病和1型糖尿病的发生有关。在这项研究中，我们调查了DPP4活性是否与健康年轻人肥胖和/或糖尿病的临床参数相关。测量了165名受试者（男性110人，女性55人，年龄23.2±2.4岁）的体重指数（HMI）、血浆DPP4活性、总胆固醇、高密度脂蛋白（HDL）胆固醇、甘油三酯、空腹血糖、脂联素浓度和体脂。在相关分析中，DPP4活性与BMI （p = 5.5 x 10(-5)）和总胆固醇（p = 0.0014）呈强正相关，与血浆脂联素浓度（p = 0.013）呈负相关，但与空腹血糖无关。我们的研究结果表明，血浆DPP4活性与年轻人肥胖的临床参数相关，而不是与糖尿病相关。
We previously found that plasma dipeptidyl peptidase 4 (DPP4) activity was associated with the development of obesity, type 2 diabetes, and type I diabetes using animal models. In this study, we investigated whether DPP4 activity is correlated with the clinical parameters of obesity and/or diabetes in healthy young subjects. Body mass index (HMI), plasma DPP4 activity, total cholesterol, high density lipoprotein (HDL) cholesterol, triglycerides, fasting blood glucose, adiponectin concentration, and body fat were measured in 165 subjects (110 males and 55 females, age 23.2 +/- 2.4 years). In correlation analyses, DPP4 activity displayed strong positive correlations with BMI (p = 5.5 x 10(-5)) and total cholesterol (p = 0.0014), and a negative correlation with the plasma adiponectin concentration (p = 0.013), but not fasting blood glucose. Our findings suggest that plasma DPP4 activity is correlated with the clinical parameters of obesity rather than diabetes in young people.