Mucosa-Associated Lymphoid Tissue Lymphoma in Sjogren's Syndrome: Risks, Management, and Prognosis
Mucosa-Associated Lymphoid Tissue Lymphoma in Sjogren's Syndrome: Risks, Management, and Prognosis
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DOI：
10.1016/j.rdc.2008.08.006
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发表时间：
2008-11-01
影响因子：
2.3
通讯作者：
Moutsopoulos, Haralampos M.
中科院分区：
文献类型：
--
作者：
Voulgarelis, Michael;Moutsopoulos, Haralampos M.
干燥综合征是一种慢性炎症性疾病，主要影响外分泌腺。它与淋巴瘤的关系是有据可查的，其中粘膜相关淋巴组织型的唾液腺结边缘区淋巴瘤是最常见的，并构成了一种主要的疾病并发症。这些肿瘤是抗原刺激的B细胞淋巴瘤，其特征是局限性阶段，无痛临床过程，并在其他淋巴结部位复发。本文回顾了文献，并讨论了这些肿瘤的临床，组织病理学，治疗和预后方面的干燥综合征。此外，它强调了淋巴瘤发展的预测标志物。
Sjogren's syndrome is a chronic inflammatory disease primarily affecting the exocrine glands. Its association with lymphoma is well documented, with salivary extranodal marginal zone lymphomas of the mucosa-associated lymphoid tissue type being the most common and constituting a major disease complication. These neoplasms are antigen-stimulated B-cell lymphomas characterized by localized stage, indolent clinical course, and recurrence in other extranodal sites. This article presents a review of the literature and discusses the clinical, histopathologic, therapeutic, and prognostic aspects of these tumors in Sjogren's syndrome. In addition, it highlights the predictor markers of lymphoma development.