A systematic overview of the incidence of posterior capsule opacification
A systematic overview of the incidence of posterior capsule opacification
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DOI：
10.1016/s0161-6420(98)97023-3
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发表时间：
1998-07-01
期刊：
影响因子：
13.7
通讯作者：
Glynn, RJ
中科院分区：
文献类型：
--
作者：
Schaumberg, DA;Dana, MR;Glynn, RJ
目的：报告的后囊膜混浊（PCO）发生率差异很大，并且基于PCO的各种定义、不同的随访时间和间隔以及不同手术技术、人工透镜（IOL）设计和IOL植入方法的使用。本研究的目的是获得一个更精确的总体估计的发生率的PCO和探讨因素，可能会影响率的PCO的发展。设计：荟萃分析。方法：基于计算机MEDLINE文献检索和相关文献参考书目的手动检索，选择已发表的文章进行研究，对符合选定纳入标准的文章进行系统综述，主要结果测量：术后1年、3年和5年发生PCO的患眼比例的汇总估计值。结果：已发表的PCO发生率存在显著异质性。术后1年、3年和5年PCO发生率的总体汇总估计值（95%置信限）分别为11.8%（9.3%-14.3%）、20.7%（16.6%-24.9%）和28.4%（18.4%-38.4%）。没有证据表明PCO的发病率显着下降，在研究periods.Conclusions：超过25%的患者接受标准的囊外白内障摘除术或超声乳化白内障吸除术与后房型人工透镜植入手术后的第一个5年，视觉显着的PCO的发展。患者特征、手术技术以及研究设计和报告的差异可能是报告发生率变化的原因。然而，在作者的分析中没有确定具体的因素。更精确地估计PCO的发病率和识别PCO的危险因素将取决于PCO标准化测量的发展和更广泛地采用更严格的研究方法。
Objective: Reported rates of posterior capsule opacification (PCO) vary widely and are based on various definitions of PCO, varying lengths and intervals of follow-up, and the use of different surgical techniques, intraocular lens (IOL) designs, and methods of IOL implantation. This study was designed to obtain a more precise overall estimate of the incidence of PCO and to explore factors that might influence the rate of PCO development.Design: A meta-analysis.Methods: Published articles were selected for study based on a computerized MEDLINE search of the literature and a manual search of the bibliographies of relevant articles, Articles meeting selected inclusion criteria were reviewed systematically, and the reported data were abstracted and synthesized using the statistical techniques of meta-analysis.Main Outcome Measure: Pooled estimates of the proportion of eyes developing PCO at three postoperative timepoints-1 year, 3 years, and 5 years-were measured.Results: There is significant heterogeneity among published rates of PCO. The overall pooled estimates (95% confidence limits) of the incidence of PCO were 11.8% (9.3%-14.3%) at 1 year, 20.7% (16.6%-24.9%) at 3 years, and 28.4% (18.4%-38.4%) at 5 years after surgery. There is no evidence of a significant decline in PCO incidence during the study period.Conclusions: Visually significant PCO develops in more than 25% of patients undergoing standard extracapsular cataract extraction or phacoemulsification with posterior chamber intraocular lens implantation over the first 5 years after surgery. Patient characteristics, surgical techniques, and differences in research design and reporting may account for some of the variability in reported rates. However, no specific factors were identified in the authors' analysis. More precise estimates of incidence and identification of risk factors for PCO will depend on the development of a standardized measurement of PCO and wider adoption of more rigorous study methodology.