Dual role of the Drosophila pattern gene tailless in embryonic termini.
Dual role of the Drosophila pattern gene tailless in embryonic termini.
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DOI：
10.1126/science.1925599
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发表时间：
1991-10
期刊：
影响因子：
56.9
通讯作者：
E. Steingrímsson;F. Pignoni;G. Liaw;J. Lengyel
中科院分区：
文献类型：
--
作者：
E. Steingrímsson;F. Pignoni;G. Liaw;J. Lengyel
无尾基因（tll）是形成果蝇胚胎末端结构域所需的第一个合子活性基因。tll基因的表达在母体末端基因torso（tor）的功能获得性突变体中异位激活;这表明tor通常在末端激活tll基因。在诱导型启动子的控制下，tll的异位表达导致异位末端特异性结构Filzkörper的分化，并导致形成这些结构所需的至少一个基因hunchback的激活。tll基因的异位表达也通过抑制差距基因Krüppel和knirps以及可能还有配对规则基因来抑制分割。
One of the first zygotically active genes required for formation of the terminal domains of the Drosophila embryo is tailless (tll). Expression of the tll gene is activated ectopically in gain-of-function mutants of the maternal terminal gene torso (tor); this suggests that tor normally activates the tll gene in the termini. Ectopic expression of tll under the control of an inducible promoter results in differentiation of ectopic terminal-specific structures, the Filzkörper, and leads to the activation of at least one gene, hunchback, that is required to form these structures. Ectopic expression of the tll gene also represses segmentation by repressing the gap genes Krüppel and knirps and probably also pair rule genes.